小青龙对磺胺甲基异噁唑在上呼吸道分布的影响

The influence of Xiaoqinglong on the distribution of sulfamethoxazole in respiratory tract

目的 :研究小青龙对磺胺甲基异唑 ( SMZ)在风寒型上呼吸道感染病人呼吸道中分布的影响。 方法 :12名风寒型上呼吸道感染病人 ,分成两组 ,每组 6人 ,一组连续服用复方 SMZ片 6d,另一组服用复方 SMZ片与小青龙 ,采用 HPL C法测定 SMZ在血及痰液中的浓度。比较服用与未服用小青龙者痰液与血液中 SMZ浓度的比例变化。结果 :服用小青龙的病人 ,比例为 ( 64 .66± 5 .65 ) % ,未服用者 ( 4 4.0 1± 3 .64 ) % ,两组之间存在显著性差异 ( P<0 .0 1)。 结论 :小青龙能有效提高风寒型上呼吸道感染病人痰液中

Objective: To investigate the influence of Xiaoqinglong on the distribution of sulfamethoxazole in respiratory tract of patients with upper respiratory infection. Methods: Twelve patients with upper respiratory infection were divided randomly into 2 groups. One group was administered with SMZ alone and the another received SMZ in combination with Xiaoqinglong tablets. The concentrations of sulfamethoxazole in sputum and blood were measured by HPLC method and the ratio of the concentrations of SMZ in sputum to serum was compared between the 2 groups. Results: The ratio of the group receiving SMZ and Xiaoqinglong tablets increased significantly as compared with that of the group receiving SMZ alone being (64.66±5.65)% and (44.01±3.64)%, respectively. Conclusion: Xiaoqinglong can effectively rise the concentration of sulfamethoxazole in sputum of patients with upper respiratory infection. [