摘要
妊娠期胃食管反流病 ( GERD)的治疗是颇具挑战性的 ,最为强调的是生活方式和饮食调节 ;一线治疗药物是非系统性吸收的抗酸剂、粘膜保护剂 ;H2 受体阻滞剂应用历史较长、临床监测资料多 ,目前还是治疗中、重度妊娠期 GERD的相对安全药物 (尼扎替丁除外 ) ;质子泵抑制剂对胎儿的不良反应尚需进一步观察 ,建议在有顽固性 GERD症状、其他药物疗效不显著时应用 ,且尽量避免在妊娠早期应用。倾向于不用促动力剂。对妊娠期 GERD的治疗 ,最为安全、有效的方案是用尽可能少的全身性作用药物来缓解或消除症状 。
Therapy of gastroesophageal reflux disease(GERD) during pregnancy is a special challenge. Life style and dietary regulation are basal and very important measures. Drugs with little to no systemic absorption including antacid and mucosa protective agents are first choices. H 2 receptor antagonists (H 2RA) have been used for long time and many safety records have been accumulated. They are relatively safe in therapy of moderate to severe GERD(except nizatidine). Further monitoring of adverse effects of proton pump inhibitors (PPI) on fetus is warranted. PPI is recommended for refractory GERD symptoms in late pregnancy. Prokinetic agents are not indicated in pregnancy. Use of the least possible amount of drugs with systemic action to ameliorate symptoms is the safest and best therapy of GERD during pregnancy. [
出处
《药学服务与研究》
CAS
CSCD
2003年第2期123-125,共3页
Pharmaceutical Care and Research
关键词
胃食管反流
妊娠
药物疗法
gastroesophageal reflux
pregnancy
drug therapy
