脑胶质瘤病临床及病理分析

Clinical and pathological analysis on gliomatosis cerebri

目的 观察脑胶质瘤病的临床、病理、磁共振成像 (MRI)特征 ,寻找本病患者生前确诊的方法。方法 对高度怀疑脑胶质瘤病患者 3例进行脑组织活检 ,将临床症状、影像学特点及病理结果进行对照研究。结果 3例患者有进行性加重的头痛、呕吐等颅内压力增高表现 ,并伴有智能与精神障碍、癫痫、偏瘫等症状。影像学显示双侧大脑半球对称性弥漫性病灶 ,并灰白质均受累 ,占位效应不明显 ,没有显著强化。肿瘤细胞在大脑半球灰白质中广泛增殖 ,主要在血管、神经元周围呈浸润性生长 ,不形成团块。结论 脑胶质瘤病的临床表现与影像学结合可帮助诊断 。

Objective To analyze the clinicopathological characters and MRI features of gliomatosis cerebri(GC).Methods Three cases with GC were analyzed on their clinical,radiological manifestations as well as pathological sections.Results All cases had headache,intracranial hypertension,and were complicated with mental retardation,or dementia epilepsy,and hemisparesis.CT showed only slightly abnormal changes.MRI revealed diffuse lesions in both hemispheres without formation of a tumor mass.Histological examination showed the tumour diffusely infiltrates both cerebral hemispheres with perineural,perivascular involvement,but no masses were formed.Conclusion The clinical and radiological features were helpful in diagnosis of GC,however confirmation by brain biopsy is needed.