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脑缺血大鼠大脑皮层和室管膜下区细胞增殖及巢蛋白表达 被引量：1

Cell proliferation and nestin expression in cortex and SEZ of MCAO rats
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摘要 目的 :探讨脑缺血损伤对大鼠脑皮层和室管膜下区细胞增殖及巢蛋白表达的影响。方法 :采用大鼠局灶性脑缺血模型 ,观察大脑皮层和室管膜下区的细胞增殖及巢蛋白阳性细胞表达。结果 :脑缺血大鼠室管膜下区细胞增殖明显增加 ,巢蛋白阳性细胞表达也显著增加 ;大脑皮层细胞增殖无明显改变 ,但巢蛋白阳性细胞表达则明显增加。结论 :脑缺血损伤可激活室管膜下区与大脑皮层神经干细胞。 AIM: To explore the effect of brain ischemia injury on cell proliferation and nestin expression in cortex and subependymal zone (SEZ). METHODS: Using a local brain ischemia model(MCAO), BrdU positive cells of cortex and subependymal zone (SEZ), also nestin positive cells, were observed by immunohistochemistry. RESULTS: BrdU and nestin positive cells in SEZ of MCAO rats were obviously increased. In cortex, only nestin positive cells were observed. CONCLUSION: Neural stem cells in SEZ and cortex were activated after brain ischemia, it may be related with neural recovery after brain ischemia injury.
作者 陈虎 蔡定芳 梁辉 程介士
机构地区 复旦大学附属中山医院 复旦大学上海医学院神经生物学国家重点实验室
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2003年第7期917-919,T004,共4页 Chinese Journal of Pathophysiology
基金 国家自然科学基金资助项目(No .30 2 716 39) 上海市卫生局中医药重大项目(杏林 2 0 0 0 - 3)
关键词 脑缺血 大鼠 干细胞 大脑皮质 室管膜下区 巢蛋白 Brain ischemia Rats Stem cells Cerebral cortex Subependymal zone Nestin
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献8

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共引文献44

同被引文献14

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中国病理生理杂志
2003年 第7期

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