摘要
目的 :了解甘氨酸 (GLY)对脂多糖 (LPS)诱导脂多糖结合蛋白 (LBP)mRNA表达的影响。方法 :用RT-PCR方法检测LPS作用下大鼠肝组织LBPmRNA的表达水平 ,并在此基础上观察甘氨酸对LPS诱导大鼠肝组织LBPmRNA表达的影响。结果 :LPS组大鼠肝组织LBPmRNA表达高于control组 (P <0 .0 1) ,GLY +LPS组大鼠肝组织LBPmRNA表达低于LPS组 (P <0 .0 1)。结论 :LPS可诱导大鼠肝组织LBPmRNA的表达 。
AIM: To study the influence of glycine(GLY) on lipopolysaccharide-binding protein(LBP) mRNA expression induced by LPS. METHODS: The level of LBP mRNA expression in liver tissues of rats was examined by RT-PCR,and the effects of glycine on LBP mRNA expression in liver tissues of rats induced by LPS were investigated. RESULTS: The level of LBP mRNA expression in hepatic tissue of rats in the LPS group was significantly higher than that in the control group( P< 0.01),the level of LBP mRNA expression in the hepatic tissue of rats in the LPS+GLY group was lower than that in the LPS group( P< 0.01). CONCLUSION: LPS can induce LBP mRNA expression in the hepatic tissue of rats, glycine can inhibit LBP mRNA expression in the hepatic tissue of rats treated by LPS.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2003年第7期920-922,共3页
Chinese Journal of Pathophysiology
基金
国家自然科学基金资助项目(No .39870 36 0 )
广东省自然科学基金项目资助项目 (No.980 70 6 )
关键词
甘氨酸
脂多糖类
脂多糖结合蛋白
Glycine
Lipopolysaccharides
Lipopolysaccharide binding protein
