5Mizuno Y, Yoshimura M, Yasue H, et al. Aldosterone production isactivated in failing ventricle in humans[J].Circulation, 2001,103 (10) : 72.
6Mark A. Spironolactone for heart failure[J]. Med Lett Drags Ther, 1999,41 (1061) : 81-82.
7Pitt B, Zannad F, Remme W J, et al. The effect of spironolactone on the morbidity and mortality in patients with severe heart failure[J]. N Eng J Med,1999,341(10) :709.
8Berry C,Mcmurray J J. Serious adverse events experienced by patients with chronic heart failure takin spironolactone [J].Heart,2001,85(4) :8.
9Zannad F, Dousset B, Alia F. Treatment of congestive heart failure. Interfering the aldosterone-cardiac extracellular relationship[J]. Hypertension, 2001,38(11) : 1227.
10Tsutamoto T, Wada A, Maeda K, et al. Effect of spironolactone. On plasma brain natriuretic peptide and left ventricular remodeling in patients with congestive heart failure[J]. J Am Coll Cardiol,2001,37(5) : 1228-1233.
5[1]Kornel L, Ramsay C, Kanamarlapudi N, et al. Evidence for the presence in arterial walls of intracellular-molecular mechanism for action of mineralocorticoids. Clin Exp Hypertens, 1982, 4: 1561
6[2]Paul M, Waganer J, Dzau VJ, et al. Gene expression of the renin-angiotensin system in humen tissues. Quantitative analysis by the polymerase chain reaction. J Clin Invest, 1993, 91(5): 2058
8[4]Baker KM, Booz GW, Dostal DE, et al. Cardiac actions of angiotensin Ⅱ: Role of an intracarcliac renin-angiotensin system. Annu Rev Physiol, 1992, 54: 227
9[5]Keeley FW, Elmoselhi A, Leenen FH, et al. Enalapril suppresses normal accumulation of elastin and collagen in cardiovascular tissues of growing rats. Am J Ph ysiol, 1992, 262: H1013
10[6]Laragh JH. New angiotension converting enzyme inhibitors. Their role in the management of hypertension. Am J Hypertens,1990,3(11): 2575
1Pitt B,Zannad F,Remme W J,et al.The effect of spironolactone on the morbidity and mortality in patients with severe heart failure[J].N Eng,J Med,1999,341(10):709
2Pitt B,Zannad F,Remme WJ,et al.The effect of spironolacton on mobiditg and mortality in patients with sevete heart failure[J].N Engl J Med,1999,341(10):709-717.
3Bonvalet JP,Alfaidy N,farman N,et al.ALDosterone intracllular receptors in human heart[J].Eur heart J,1995,16(Suppl N):92-103.
4Rocha R,Williams GH.Rationale for the use of aldosterone antagonists in congestive heart failure[J].Drugs,2002,62 (5):723-731.
5Delcayre C,Silvestre JS.Aldosterone and the heart:towards a physiological function?[J].Cardiovascular Res,1999,43(1):7-12.