摘要
目的探讨肿瘤坏死因子 α(TNF α)和细胞间粘附分子 1(ICAM 1)在慢性阻塞性肺疾病 (COPD)发病机制中的作用。方法采用放射免疫法检测 38例COPD患者血清TNF α和ICAM 1水平 ,并以 30例健康人作为对照。结果在COPD急性感染期 ,患者血清TNF α和ICAM 1水平显著高于感染控制期和健康对照组 (P <0 .0 1) ;而且重症感染患者血清TNF α和ICAM 1水平显著高于轻症患者 (P <0 .0 5 )。结论TNF α和ICAM 1参与了COPD肺部感染的发病过程 ,并可作为COPD患者判断病情的一项感染监测指标。
Objective To explore the significance of serum tumor necrosis factor-α(TNF-α) and intercellular adhension molecule-1(ICAM-1) in the patients with chronic obstructive pulmonary disease(COPD). Methods TNF-α and ICAM-1 levels of 38 COPD patients were measured by use of radioimmunoassay and 30 healthy subjects served as controls. Results The serum levels of TNF-α and ICAM-1 of COPD patients at the acute infection stage were significantly higher than those of healthy controls and those at infection control stage(P<0.01). TNF-α and ICAM-1 levels in severe cases were higher than those of patients with mild symptoms(P<0.05). Conclusion TNF-α and ICAM-1 are involved into the progression of COPD infection, which can serve as an infection monitoring index to judge the disease condition.
出处
《中国综合临床》
北大核心
2003年第8期691-692,共2页
Clinical Medicine of China
关键词
慢性阻塞性肺疾病
肿瘤坏死因子-Α
细胞间粘附分子-1
Chronic obstructive pulmonary disease
Tumor necrosis factor-α
Intercellular adhension molecule-1