血清肿瘤坏死因子和细胞间粘附分子在慢性阻塞性肺疾病患者肺部感染中的意义

The significance of serum tumor necrosis factor-α and intercellular adhension molecule in the lung infection of the patients with chronic obstructive pulmonary disease

目的探讨肿瘤坏死因子 α(TNF α)和细胞间粘附分子 1(ICAM 1)在慢性阻塞性肺疾病 (COPD)发病机制中的作用。方法采用放射免疫法检测 38例COPD患者血清TNF α和ICAM 1水平 ,并以 30例健康人作为对照。结果在COPD急性感染期 ,患者血清TNF α和ICAM 1水平显著高于感染控制期和健康对照组 (P <0 .0 1) ;而且重症感染患者血清TNF α和ICAM 1水平显著高于轻症患者 (P <0 .0 5 )。结论TNF α和ICAM 1参与了COPD肺部感染的发病过程 ,并可作为COPD患者判断病情的一项感染监测指标。

Objective To explore the significance of serum tumor necrosis factor-α(TNF-α) and intercellular adhension molecule-1(ICAM-1) in the patients with chronic obstructive pulmonary disease(COPD). Methods TNF-α and ICAM-1 levels of 38 COPD patients were measured by use of radioimmunoassay and 30 healthy subjects served as controls. Results The serum levels of TNF-α and ICAM-1 of COPD patients at the acute infection stage were significantly higher than those of healthy controls and those at infection control stage(P<0.01). TNF-α and ICAM-1 levels in severe cases were higher than those of patients with mild symptoms(P<0.05). Conclusion TNF-α and ICAM-1 are involved into the progression of COPD infection, which can serve as an infection monitoring index to judge the disease condition.