1-(6-甲氧基-2-萘基)乙醇的合成

Synthesis of 1-(6-Methoxy-2-naphthyl)ethanol

2 甲氧基萘经1,3 二溴 5,5 二甲基乙内酰脲盐酸催化溴化、Friedel Crafts乙酰化得到5 溴 6 甲氧基 2 乙酰基萘。在KOH、n BuOH和Et3N溶液中、w(Pd)=10%的Pd/C催化下,于60℃和常压下用H2氢化5 溴 6 甲氧基 2 乙酰基萘得1 (6 甲氧基 2 萘基)乙醇,收率98 7%。合成总收率94%(以2 甲氧基萘计)。

1(6Methoxy2naphthyl)ethanol was synthesized from 2methoxynaphthalene in total yield of 94% by hydrochloric acidcatalysed bromination with 1,3dibromo5,5dimethylhydantoin,FriedelCrafts acetylation and catalytic hydrogenation in a multiphase system.The intermediate product 5bromo6methoxy2acetylnaphthalene was hydrogenated in a solution of nBuOH,10% KOH and Et3N,with Pd/C as catalyst,by bubbling H2 at 60 ℃ for 1 h to give 1(6methoxy2naphthyl) ethanol in 987% yield.