三苯氧胺治疗乳腺癌引发卵巢囊肿的临床分析

Clinical analysis of the treatment of ovarian cyst induced by breast cancer with tamoxifen

目的探讨乳腺癌患者服用三苯氧胺后卵巢囊肿的发生情况。方法 93例服用三苯氧胺的乳腺癌患者为观察组 ,2 3例未服用三苯氧胺患者为对照组。结果观察组发现卵巢囊肿 18例 ,发生率 19.35 % ,明显高于对照组 ,随访中囊肿缩小或停药后缩小。未绝经和绝经不足 1年的患者 ,其卵巢囊肿发生率为 38.5 % ,月经规律患者发生率为 6 8.2 %。对照组无卵巢囊肿发生。结论卵巢囊肿是乳腺癌患者服用三苯氧胺的常见副作用 ,主要发生于尚未绝经或绝经不足 1年的患者 ,囊肿能自行消失或停药后消失。

Objective To investigate the effect of tamoxifen on ovarian cyst induced by breast cancer. Methods 93 patients with breast cancer treated by tamoxifen were taken as observation group and 23 patients with breast cancer untreated with tamoxifen were taken as control group. Results 18 cases of observation group were found to have ovarian cyst, with the incidence rate of 19.35%, obviously higher than control group, whose cyst decreased or decreased after stopping medication during follow-up. The incidence rate of ovarian cyst was 38.5% for the patients without menopause and the patients with less than 1-year menopause, which was 68.2% for the patients with regular menorrhea, but ovarian cyst did not occur in the control group. Conclusion Ovarian cyst is the main side effect of tamoxifen for treating ovarian cyst in the patients with breast cancer, which mainly develops in the patients without menopause or with less than 1-year menopause. The cyst can disappear spontaneously or disappear after stopping medication.