心理干预对肿瘤患者情绪及免疫功能的影响

Psychological intervention on emotional disorder and immunological functions in patients with tumors

目的 通过心理干预观察肿瘤患者的情绪障碍及免疫功能的改变 ,探讨其临床意义。方法 对 68例合并有情绪障碍的肿瘤患者随机分成干预组 (n =3 5 )与对照组 (n =3 3 ) ,对照组仅给予抗肿瘤治疗 ,干预组则在抗肿瘤治疗的基础上进行健康教育及心理干预 ,情绪障碍严重者服用适量抗情绪障碍药物治疗 ,三个月后进行SDS、SAS、HRSD、HAMA评估并复测免疫指标。结果 三个月后干预组SDS、SAS、HRSD、HAMA评分显著低于对照组 (P <0 .0 5或 0 .0 1)。IgG、IgM ,CD3 + 、CD4+ 、CD8+ 及CD16+ 等免疫参数干预组较对照组明显改善 (P <0 .0 5或 0 .0 1)。结论 心理干预不仅有助于肿瘤患者情绪障碍的改善 ,而且有益于肿瘤患者自身免疫功能的提高。

Objective To study the effect of psychological intervention on emotional disorder and immunological function in patients with tumors . Method 68 tumor patients with emotional disorder were randomly divided into intervention group (n=35) and control group (n=33) , the former received health education and supportive therapy , some with major depression received antidepressant for 3 months . Three months later , both groups were assessed with SDS, SAS, HRSD and HAMA again , as well as assessments of their immune function by measuring serum IgG , IgA , IgM, C3 , C4 and sub groups of lymphocyte.Results The scores of SDS ,SAS, HRSD and HAMA in intervention group were lower 3 months later than the control group (P<0.05 or 0.01). The levels of IgG, IgM and CD 3 +, CD 4 +, CD 8 +, CD 16 + in intervention group were higher 3 months later than the control group (P<0.05 or 0.01) . Conclusion Psychological intervention has positive effect on emotional disorder and immunological functions in patient with tumors .