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PLGA微球控释系统的突释及其控制 被引量：21

Study on Initial Burst Release in PLGA Microspheres Controlled Delivery Systems
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摘要 针对目前限制 PL GA微球控释系统临床应用的突释问题 ,重点介绍了近年来国内外有关的研究进展 ,包括突释现象、突释原因。 Initial burst release is one of the main obstacles to the clinical application of poly(D,L lactide co glycolide) (PLGA) microspheres controlled drug delivery systems. The article reviews the experimental observations of initial burst release, the factors causing burst release and some methods to control burst release in PLGA microspheres controlled drug delivery systems.
作者 王峰 涂家生 张钧寿 卢晶
机构地区 中国药科大学药剂教研室
出处 《药学进展》 CAS 2003年第3期142-146,共5页 Progress in Pharmaceutical Sciences
关键词 聚乳酸-羟基乙酸 微球控释系统 突释 影响因素 Initial burst release PLGA Microspheres Controlled release systems
分类号 R94 [医药卫生—药剂学]
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参考文献25

  • 1朱家蕙,沈正荣,王芳,马臻.含睾丸酮的乳酸-乙醇酸共聚物微球的制备及体外药物释放[J].中国药学杂志,1997,32(10):595-598. 被引量：14
  • 2李学明,涂家生,何飞.生物降解型尼索地平微球的研究[J].中国药科大学学报,2001,32(5):346-349. 被引量：4
  • 3Wang J, Wang B M ,Schwendeman S P. Characterization of the initial burst release of a model peptide from poly(d, I-lactide-co-glycolide)microspheres[J].J Control Release 2002,82(2-3):289-307
  • 4Takenaga M, Yamaguchi Y, Kitagawa A, et al. A novel sustained-release formulation of insulin with dramatic reduction in initial rapid release[J]. J Control Release,2002,79(1-3):81-91.
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  • 7Kim H K,Park T O. Microencapsulation of Human Growth Hormone within biodegradable polyester microspheres: protein aggregation stability and incomplete release mechanism[J].Biotechnol Bioeng, 1999,65(6):660-667.
  • 8Jiang G, Woo B H, Kang F, et al. Assessment of protein release kinetics, stability and protein polymer interaction of lysozyme encapsulated poly (d, 1-Lactice-co-glycolide) microsphercs[J]. J Coatrol Release,2002,79(1-3):137-145
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药学进展
2003年 第3期

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