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血管抑素的研究近况 被引量：2

Research Status for Angiostatin
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摘要 综述了有关血管抑素及其受体、作用方式、影响作用的因素等问题的研究现状 ,并对其在肿瘤的治疗和新药开发中的意义进行了展望。 The discovery of angiostatin presents a new way to cure tumor. The paper reviews the present research in the receptor, acting mechanism and influencial factors for the effect of angiostatin. The significance of angiostatin for developing antitumors is inferred, too.
作者 张金赫 徐海峰 周润锁
机构地区 第四军医大学唐都医院核医学科
出处 《药学进展》 CAS 2003年第3期147-150,共4页 Progress in Pharmaceutical Sciences
关键词 血管抑素 肿瘤 血管生成 细胞凋亡 PH值 一氧化氮合酶 Angiostatin Mechanism of action Antitumor
分类号 R96 [医药卫生—药理学]
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参考文献21

  • 1O'Reilly M S, Holmgren L, Shing Y, et al. Angiostatin : a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma[J]. Cell, 1994,79(2);315-328.
  • 2Grfffioen A W, Molema G . Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation[J].Pharmacol Rev, 2000,52(2) :237-268.
  • 3Chavakis E, Dimmeler S. Regulation of endothelial cell survival and apoptosis during angiogenesis[J].Arterisocler Thromb Vasc Biol, 2002, 22(6):887-893.
  • 4Moser T L, Kenan D J, Ashley TA, et al. Endothelial cell surface F1-F0 ATP synthase is active in ATP synthesis and is inhibited by angiostatin[J]. Proc Natl Acod Sci USA,2001,98(12):6656-6661.
  • 5Moser T L, Stack M S, Asplin I, et al. Angiostatin binds ATP synthase on the surface of human endothelial cells[J].Proc Natl Acad Sci USA, 1999, 96(6) : 2811-2816.
  • 6Takehiko Tarui, Mousumi Majumdar, Lindsey A ,et al. Plasmin-induced migration of endothelial cells: a potential target for the anti-angiogenic action of angiostatin[J]. J Biol Chem,2002.
  • 7Tarui T, Miles LA, Takada Y. Specific interaction of angiostatin with integrin alpha(v)beta(3) in endothelial cells[J].J Biol Chem,2001, 276(43) : 39562-39568.
  • 8Troyanovsky B, Levchenko T, Mansson G,et al. Angiomotin: an angiostatin binding protein that regulates endothelial cell migration and tube formation[J]. J Cell Biol, 2001,152(6): 1247-1254.
  • 9Jun Liu, Babak Razani, Shaoqing Tang, et al. Angiogenesis Activators and Inhibitors Differentially Regulate Caveolin-1 Expression and Caveolae Formation in Vascular Endothelial Cells[J]. J Biol Chem, 1999, 274(22): 15781-15785.
  • 10Benelli R, Morini M, Carrozzino F,et al. Neutrophils as a key cellular target for angiostatin implications for regulation of angiogenesis and inflammation[J].FABES J, 2002, 16(2) :267-269.

同被引文献12

  • 1张金赫,徐海峰,邵秋菊,周飞华,周润锁,袁梦晖,郭万宏.^(99)Tc^m直接法标记Angiostatin及其在荷瘤小鼠体内研究[J].第四军医大学学报,2004,25(17):1625-1627. 被引量：5
  • 2Augustin HG. Aantiangiogenic tumor therapy: will it work?[J]. Trends Pharmacol Sci, 1998, 19 (3): 216-222.
  • 3Kolkman J. Fighting cancer by attacking its blood supply [J].Sci Am, 1996, 275 (2): 150-154.
  • 4Ji WR, Barrientos LG, Linas M, et al. Selective inhibition by kringle 5 of human plasminogen on endothelial cell migration,an important process in angiogenesis [J]. Biochem Biophys ResCommu, 1998, 247 (2): 414-419.
  • 5Mose TL, Stack MS, Asplin I, et al. Angiostatin binds ATP synthase on the surface of human endothelial cells [J]. Proc Natl Acad Sci USA, 1999, 96 (6): 2811-2816.
  • 6Cao Y. Therapeutic potentials of angiostatin in the treatment of cancer. Haematologica 1999; 84:643 -50.
  • 7O' Reilly MS, Holmgren L, Shing Y, et al. Angiostatin: a noval angiogenesis inhabitor that mediayes the suppression of metastases by Lewis lung carcinoma. Cell 1994; 79:315 -28.
  • 8Zhang JH, Xu HF, Shao QJ, et al. 99Tcm-direct labeling of angiostatin. J Med Coll PLA 2004: 19(1): 35 -8.
  • 9Gano L, Patricio L, Marques E, et al. Human polyclonal immunoglobulin labeled with technetium-99m via NHS-MAG3: a comparison of radiochemical behavior and biological efficacy with other labeling methods. Nucl Med Biol 1998; 25 (4):395 - 403.
  • 10薛刚,姚榛祥.甲状腺癌的微血管密度及其临床意义[J].中华外科杂志,2000,38(8):636-636. 被引量：13

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药学进展
2003年 第3期

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