艾滋病病毒感染者合并丙型肝炎病毒感染的临床研究

Study on clinical laboratory tests in HIV/HCV coinfection patients

目的 探讨人类免疫缺陷病毒 (HIV)和丙型肝炎病毒 (HCV)混合感染的临床特点。方法 收集 2 8份HIV合并HCV感染血清、血浆和 2 4份单纯HIV阳性血清、血浆。进行HIV、HCV载量、T淋巴细胞、血常规、肝功能等检测 ,分析 2组实验室检测指标的差别。结果 HIV合并感染者的HCV载量与各项检测指标无明显相关性。HIV感染组的HIV载量 (4 8± 0 9lg拷贝 /ml)高于HIV合并感染组 [(4 1± 1 0 )lg拷贝 /ml,P <0 0 5 ],而前者红细胞和血红蛋白值低于后者 (P <0 0 5 )。HIV合并感染组的丙氨酸转氨酶异常者 [(87 0± 6 9 6 )U/L ,占 6 4 % ]明显高于HIV感染组 [(2 0 6± 13 6 )U/L ,占 10 % ,P <0 0 1]。结论 HIV合并感染组的HIV载量低于HIV感染组 ,而肝功能损害明显重于HIV感染组 ,HCV载量与各项实验室指标无明显相关性。

Objective To study the clinic laboratory characters of HIV/HCV coinfection patients. Methods HIV load, HCV load, T lymphocytes, liver function, blood routine test were determined by the regular immunological, biochemical, and molecular biological methods. Results HCV load showed little correlation with the result of clinic laboratory tests for HIV and liver function. Individuals only infected with HIV showed higher HIV load [(4.8±0.9 )lg copies/ml] than those co-infected with HCV [(4.1±1.0) lg copies/ml, P<0.05]. However the RBC and Hb were lower in the former group(P<0.05).Coinfection with HCV may lead to increase of serum transaminases(P<0.01),the abnormal increase in serum transaminases account for 64% of patients co-infected with HCV, while the rate was only 10% for the infected persons.Conclusion Co-infection with HCV may result in a lower HIV load, while the hepatic damage were more seriously than those only infected with HIV. HCV load showed little correlation with clinic laboratory items.