p27^(kip1)在原发性肝细胞癌中的表达及其临床意义

Expression and Clinical Significance of p27^(kip1) in Hepatocellular Carcinoma

目的 研究p2 7kip1在原发性肝细胞癌 (HCC)中的表达及其临床意义。方法 应用免疫组化S -P法检测 4 0例HCC、15例肝硬化组织和 5例正常肝组织石蜡标本中 p2 7kip1的表达。 结果 p2 7kip1蛋白在 4 0例HCC中表达阳性率为 32 .5 % (13/40 ) ,在 15例肝硬化组织中为 6 0 % (9/15 ) ,在 5例正常肝组织中为 80 % (4/5 )。p2 7kip1蛋白在HCC中的表达与其在肝硬化组织和正常肝组织中的表达相比有显著性差异 (P <0 .0 5 ) ,p2 7kip1蛋白与HCC的组织学分级、组织学类型、淋巴结转移、远处转移和生存期均有统计学差异。结论 p2 7kip1与HCC的发生、发展可能均有密切联系 ,p2 7kip1蛋白在一定程度上可判断患者的病情进展和预后。

Objective To study the expression and clinical significance of p27 kip1 in hepatocellular carcinoma. Methods p27 kip1 was detected by S-P immunohistochemical method in 40 cases of hepatocellular carcinoma,15 cases of hepatic cirrhosis and 5 cases of normal liver of paraffin-embedded sections of hepatocellular carcinoma. Results The positive rate of p27 kip1 protein in 40 cases of hepatocellular carcinoma was 32.5%(13/40),60% (9/15)in hepatic cirrhosis,and 80% (4/5) in normal liver.The difference between them was prominent ( P <0.05),statistical correlation existed between p27 kip1 protein and the histological differentiation,histological size,lymph node metastasis,distance metastasis and survival. Conclusion p27 kip1 protein may correlate with HCC and p27 kip1 protein level can be used in preiction of the progression and prognosis of HCC.