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儿童神经系统疾病血清、脑脊液神经元特异性烯醇酶变化的意义 被引量:3

Value of neuron-specific enolase concentration changes in sera and cerebrospinal fluids in evaluating children with neurological disorders
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摘要 目的 探讨血清、脑脊液神经元特异性烯醇酶 (NSE)在神经系统疾病中的意义。方法 采用电化学发光法检测 85例神经系统疾病血清 ,脑脊液NSE活性。结果 病毒性脑炎 (病脑 )、癫、高热惊厥 (FC)患儿血清NSE含量均明显高于对照组 (P <0 .0 0 5 ) ,而相互间无显著性差异 (P >0 .0 5 )。病脑、癫患儿脑脊液NSE与对照组比较显著升高 (P <0 .0 0 1) ,而FC组与对照组无明显差别 (P >0 .0 5 ) ,且相互间有显著性差异 (P<0 .0 5 )。结论 病脑、癫均存在脑损伤 ,血清、脑脊液NSE含量均明显升高 ,脑脊液NSE变化更具特异性 ,可作为病脑。
出处 《实用儿科临床杂志》 CAS CSCD 北大核心 2003年第6期460-461,共2页 Journal of Applied Clinical Pediatrics
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参考文献4

  • 1欧阳颖,彭茜,母发光,李茂军,张玲英,刘丽,游正芸,宋文忠.癫痫持续状态患儿血清神经元特异性烯醇酶和脑SPECT改变的意义[J].中国当代儿科杂志,2002,4(2):103-105. 被引量:7
  • 2Berger RP, Perce MC. Neuron-specific enolase and S-100B in cerebrospinal fluid after severe traumatic brain injury in infants and children [J]. Pediatrics,2002; 109(2) :E31.
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二级参考文献6

  • 1Mokuno K,Kato K,Kakai K,et al. Neuron-specific enolase and S-100 protein levels in cerebrospinal fluid of patients with various neurological diseases [J] . J Neurol Sci,1983,60(2):433.
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  • 5晏勇,王学峰,陈阳美,李国秧,沈鼎烈.癫痫患者血清神经元特异性烯醇酶的测定[J].中华神经科杂志,1999,32(1):34-36. 被引量:50
  • 6欧阳颖,彭茜,母发光,李茂军,张玲英.惊厥儿童血清神经元特异性烯醇酶与脑损伤关系的探讨[J].中国实用儿科杂志,2001,16(6):374-374. 被引量:14

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