银杏叶提取物治疗新生儿缺氧缺血性脑损伤的机制

The Mechanism of Ginkgo-Biloba Extract in the Treatment of Newborn Ischemic, Hypoxic Encephalopathy Encephalopathy

目的 探讨银杏叶提取物对新生儿缺氧缺血性脑损伤治疗作用的机制.方法 采用银杏叶提取物(GBE)治疗75例新生儿缺氧缺血性脑病(HIE),分别检测治疗前后患儿血浆中血小板活化因子(PAF)、一氧化氮(NO)和丙二醛(MDA)的含量.结果 治疗前后不同临床分度HIE患儿的PAF、NO和MDA含量均有显著性差异,临床疗效显著.结论 银杏叶提取物在治疗新生儿缺氧缺血性脑损伤方面有着较好的应用前景,其作用机理与GBE中的银杏萜内酯成分有关.

OBJECTIVE To research protective mechanism of GBE in the Newborn ischemic?hypoxic encephalopathy. METHOD 75 brain injury newborns were treated by GBE. The level of blood platelet activating factor(PAF)?NO and MDA before and after treatment were measured respectively. RESULTS There was significant difference between the levels of blood PAF, NO and MDA in per and posttreatment period. So the clinical effectiveness was remarkable. CONCLUSIONS The GBE is effective in the treatment of iscbemic, hypoxic encephalopathy of Newborn, it is related to the effective components of GBEterpenoids.