甲状腺激素估测肝衰竭预后的探讨

Evaluating the Prognosis of Hepatic Failure by Thyroid Hormone Values

目的 :探讨肝衰竭时甲状腺激素的代谢变化及其对肝衰竭估测预后的价值。方法 :对 30例肝衰竭患者检测T3、T4 ,计算出均数 ,并将肝衰竭患者按T3值高低分为甲乙两组 ,甲组T3值 <0 8nmol L ,乙组T3值≥ 0 8nmol L。结果 :肝衰竭患者T3值均数为 0 81nmol L ,低于正常 ,有显著差异 (P <0 0 5 ) ;T4 值均数为 63 3nmol L ,在正常值范围内 ;甲乙两组进行死亡率比较 ,甲组高于乙组 ,有显著差异 (P <0 0 5 )。结论 :甲状腺激素T3是评估肝衰竭预后的简单方法 ,能较好地预测预后 。

Objective:To study the changes in metabolism of thyroid hormone in the cause of hepatic failure and the roles they play in evaluating the prognosis of hepatic failure.Methods:30 cases of hepatic failure were examined to determine the values of T 3 and T 4,with mean worked out,and the patients were divided into two groups by T 3 value:Group A(T 3<0.8nmol/L)and Group B(T 3≥0.8nmol/L).Results:The mean of T 3 is 0.81nmol/L T 3 value of the patients with hepatic failure is remarkabyl lower than the normal (P<0.05).The mean of T 4 is 63.3nmol/L,Within the limits of the normal.Compared group A,the death rate is markedly higher than that in group B(P<0.05).Conclusion:Thyroid T 3 is a simple and easy way to evaluate the prognosis of hepatic failure,which helps to predict the prognosis of hepatic failure more effectively and can be accepted widely in clinical practice.