血和尿层粘连蛋白与2型糖尿病患者尿白蛋白关系的研究

Relationship between urinary,serum laminin and urinary albumin in type 2 diabetes mellitus

目的 研究血、尿层粘连蛋白 (LN)与早期糖尿病肾病 (DN)的关系。方法 2型糖尿病 (DM)患者 116例 ,分为正常蛋白尿组 (DMN组 ) 83例 ,微量蛋白尿组 (DMMA组 ) 3 3例 ;对照组 (C组 ) 3 1例。检测尿液LN、白蛋白(Alb)、肌酐 (Cr)和血清LN。结果 ①尿LN/Cr在DMMA组高于C组 (P <0 0 5 ) ;血清LN在DMMA组高于C组及DMN组 (P <0 0 5 )。②DM患者尿Alb/Cr与尿LN/Cr(r =0 183 ,P <0 0 5 )、血清LN(r =0 3 5 7,P <0 0 1)均呈显著的正相关。③DM病程进入了血、尿LN和尿Alb/Cr的回归方程。结论 ① 2型DM患者血、尿LN与尿Alb排出有一致性升高的趋势 ,血清LN是DM早期肾病标志蛋白。②整体DM组中DM病程为血、尿LN和Alb/Cr升高的危险因子。③本研究提示 2型DM患者中血、尿LN水平升高 ,并与DN的发生和严重程度有较好的相关性 ,尿、血LN水平可以用来监测DN的发生。

Objective To study the relationship between u rinary,serum laminin (LN) and urinary albumin (Alb) in type 2 diabetes mellitus.Methods Urinary,serum LN and urinary creatinine (Cr) were measure d in 116 patients with type 2 diabeties mellitus and 31 normal controls .Results ①Urinary LN/Cr in DM microalbumi nuria (DMMA) group was higher than control group (group C) (P<0 05).Serum L N le vels significantly increased in DMMA group compared with DM normoalbuminuria (DM N) group and gr oup C(P<0 05).②Urinary Alb/Cr correlated with urinary LN/Cr (r=0 183, P<0 05) and serum LN (r=0 357,P<0 01) in combined DM group.③DM duration was significantly related to serum and urinary LN a nd urinary Alb.Conclusion Serum LN is a marker for nephropathy in early DM pat ients;DM course is a risk factor of serum,urinary LN and Alb/Cr increase;urinary and serum LN can be used to monitor the onset,progress and therapeutic effec t of DN.