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加替沙星中主要杂质P-去甲加替沙星的分离、合成与结构鉴定 被引量：3

Separation of the Main Impurity P-demethylgatifloxacin from Gatifloxacin and its Synthesis and Identification
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摘要 AIM:To identify the main impurity of gatifloxacin.METHOD:P-demethylgatifloxacin was synthesized in four steps from ethyl 2-(3-methoxy-2,4,5-trifluorobenzoyl)-3-(cyclopropylamino) acrylate through cyclization,chelation,N-piperazination and hydrolysis,and identified by LC/MS,UV, 1 HNMR , 13 CNMR ,MS.RESULT:the main impurity of gatifloxacin was P-demethylgatifloxacin. AIM:To identify the main impurity of gatifloxacin.METHOD:P-demethylgatifloxacin was synthesized in four steps from ethyl 2-(3-methoxy-2,4,5-trifluorobenzoyl)-3-(cyclopropylamino) acrylate through cyclization,chelation,N-piperazination and hydrolysis,and identified by LC/MS,UV, 1 HNMR , 13 CNMR ,MS.RESULT:the main impurity of gatifloxacin was P-demethylgatifloxacin.
作者 王秀珍 王新图 王尔华
机构地区 中国药科大学医药化工研究所 南京澳新医药科技有限公司
出处 《中国药科大学学报》 CAS CSCD 北大核心 2003年第3期272-273,共2页 Journal of China Pharmaceutical University
关键词 加替沙星 P-去甲加替沙星 分离 鉴定 合成 Gatifloxacin P-demethylgatifloxacin Separation Identification Synthesis
分类号 R914 [医药卫生—药物化学]
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参考文献4

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同被引文献27

  • 1陈超森,曾卓,熊淑群.喹诺酮类药物的研究进展[J].精细化工中间体,2005,35(5):1-5. 被引量：16
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引证文献3

二级引证文献8

中国药科大学学报
2003年 第3期

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