5-氟-2-溴苯甲酸的制备实验研究

Synthesis of 2-bromo-5-fluorobenzoic acid

以乙酸为溶剂 ,乙酸钴、乙酸锰、溴化钠为催化剂 ,由氧气在常压下氧化 5 -氟 - 2 -溴甲苯制备 5 -氟 - 2 -溴苯甲酸 ,反应温度 12 0～ 130℃ ,反应物质量分数为 16 .8%～ 2 0 .2 % ,催化剂用量为原料的 2 .5 %～ 4 %时 。

Under common air pressure, 2 bromo 5 fluorotoluene is oxidized by oxygen to synthesize 2 bromo 5 fluorobenzoic acid. Acetic acid is used as solvent; acetic cobalt, acetic manganese and bromide sodium are used as catalyst. Reaction temperature ranging 120～130℃, 2 bromo 5 fluorotoluene concentration ranging 16.8%～20.2% and the catalyst dosage ranging 2.5%～4% of 2 bromo 5 fluorotoluene, the product yield is high.