E-钙粘素表达与成釉细胞瘤生物学特性的关系研究

The Relationship between Expression of Epithelial Cadherin and Biological Behavior of Ameloblastoma

目的探讨E-钙粘素与成釉细胞瘤复发和侵袭的关系。方法采用免疫组织化学LABC方法,检测28例成釉细胞瘤组织中E-钙粘素蛋白的表达。结果28例成釉细胞瘤中,12例E-钙粘素正常表达(42.9%);正常表达者的阳性物在肿瘤外层(周边)细胞的染色较强,内层(中央)细胞染色相对减弱;而在E-钙粘素异常表达者,肿瘤内层细胞阳性染色较强,外层细胞阳性染色较弱或缺失;异常表达病例的复发率明显高于正常表达者(P<0.01)。结论E-钙粘素异常表达与成釉细胞瘤复发密切相关,可能是成釉细胞瘤局部侵袭的机制之一。

Objective To investigate the relationship between expression of epit he lial cadherin and invasion and recurrence of ameloblastoma.Methods Immunohistoch emical LABC method was used in detecting the expression of epithelial cadherin i n28cases of ameloblastoma.Results The total normal expression rate of epithelial cadherin was42.9%.The stained density of the outer layer cells was higher than that of the inner layer cells in the cases with normal expression,but the staine d density of the outer layer cells was predominantly low or deletion,and lower t han that of the inner layer cells in the cases with abnormal expression.The recu rrence rate in the cases with abnormal expression was significantly higher than that in the ones with normal expression.Conclusion Abnormal expression of epithe lial cadherin may be associated with recurrent potentiality of ameloblastoma,and may be a reason of invasion in ameloblastoma.