不稳定性心绞痛、急性心肌梗死患者血清磷等8种元素变化的临床意义

Changes of serum phosphorus and seven other elements in unstable angina pectoris and acute myocardial infarction

目的 观察血清磷、钙、镁、铜、铁、锌、硒、镉 8种元素在不稳定性心绞痛 (UAP)、急性心肌梗死 (AMI)、稳定性心绞痛 (SAP)患者中的变化 ,以发现预测AMI的指标。方法 将 12 7例冠心病 (CHD)患者分为UAP组 6 6例、AMI组 4 6例、SAP组 15例 ,正常对照组 5 0例。抽取心绞痛发作或AMI发生 2 4小时内静脉血。利用电感耦合等离子体发射光谱法 (ICP AES)测定前述 8种元素在血清中的含量。随访心绞痛患者及正常人 6个月至 18个月。结果 UAP组的血清磷分别高于对照组、SAP组和AMI组 (P =0 .0 0 0 1,P =0 .0 0 0 1,P =0 .0 2 14 )。UAP组的血清钙分别高于对照组和AMI组 (P =0 .0 0 5 8,P =0 .0 0 0 9)。结论 血清磷 >170mg/L ,同时有血清钙 >10 0mg/L的UAP患者近期易发生AMI。

Objective This research has focused on how the serum phosphorus,calcium,magnesium,copper,iron,zin c,selenium,and cadmium,changes among patients suffering unstable angina pectoris (UAP)and acute myocardial infarction(AMI)and stable angina pectoris (SAP).The main purpose is to find out if the change of serum phosphorus can be used as a criteria for prediction of AMI.Methods 127 cases of hospitalized CHD patients were divided into 3 groups: 66 of them were in the group of UAP; 46 of them were in the group of AMI; 15 of them were in the group of SAP; other 50 peoples as the control group.Vein blood in fasting of the group of UAP,AMI and SAP patients were collected within 24 hours after the heart attack.The concentration values of the 8 elements were measured with the method of Inductance Coupling Plasma Emission Spectrum(ICP AES).After 6 monthes to 18 monthes follow up of 81 angina pectoris(AP)patients and the peoples of control group.Reslults The level of phosphorus was significantly higher in UAP than in control?SAP and AMI (P= 0.0001 ,P= 0.0001 ,P= 0.0214 ).The level of calcium was significantly higher in UAP than in control and AMI (P= 0.0058 ,P= 0.0009 ).Conclusion The results show that patients with both serum phosphorus grater than 170 mg/L and serum calcium greater than 100 mg/L are very likely to suffer from AMI,this can be a criteria for AMI prediction.