脂蛋白酯酶与动脉粥样硬化(英文)

Lipoprotein Lipase and Atherosclerosis

脂蛋白酯酶(lipoproteinlipase,LPL)是调节脂蛋白代谢的一种关键酶,如具有水解血浆脂蛋白中三酰甘油的作用等.体内LPL减少会导致血三酰甘油升高和高密度脂蛋白胆固醇降低,增加患动脉粥样硬化的危险.通过提高LPL的活性可以抑制动脉粥样硬化的发生发展.已有的研究说明NO 1886促进心肌和脂肪组织LPLmRNA表达,提高心肌、脂肪组织、骨骼肌和血液中LPL活性,因而改善脂蛋白代谢,抑制动脉粥样硬化.

Lipoprotein lipase (LPL) is a key enzyme in regulation of lipoprotein metabolism,especially in breaking down plasma triglycerides (TG) of TGrich lipoproteins,including chylomicrons and very low density lipoproteins (VLDL).Dysfunction of LPL contributes to hypertriglyceridemia and decreased high density lipoprotein cholesterol level,which in turn increases risk of atherosclerosis.Ppromoting LPL activity inhibit atherosclerosis was once proposed and a LPL activator to validate our hypothesis was synthesized.The completed studies have shown that NO1886 increased LPL mRNA and LPL activity in adipose tissue,myocardium and skeletal muscle,resulting in an elevation of postheparin plasma LPL activity and LPL mass,and also decreased plasma TG concentration with a concomitant rise in plasma HDLC,inhibited the development of atherosclerosis.