兔体内乳酸左氧氟沙星时辰药动学

The chronopharmacokinetics of levofloxacin lactate in rabbits

目的 :观察不同时间给药乳酸左氧氟沙星药动学变化。方法 :16只家兔在 0 8∶0 0 ,2 0∶0 0两个不同时间点按 16mg·kg- 1 口服给于乳酸左氧氟沙星片 ,于 0 .2 5 ,0 .5 ,0 .75 ,1.0 ,2 .0 ,3 .0 ,4.0 ,6.0 ,8.0 ,12 .0h取血 ,分别测定其血浆药物浓度 ,并按两房室模型计算药动学参数。结果 :家兔于 8∶0 0和 2 0∶0 0给药 ,其药动学的主要参数t1 / 2 β、AUC、Cl、V等差异无显著性 (P>0 .0 5 )。结论 :乳酸左氧氟沙星在兔体内的药动学没有明显的时间节律性变化。

OBJECTIVE To observe the change of pharmacokinetics of levofloxacin lactate in rabbits by single oral administration at different time. METHODS Sixteen rabbits were respectively given a single dose of levofloxacin lactate tablets 16 mg·kg -1 at 8∶00 and 20∶00. The blood was taken out at 0.25 , 0.5 , 0.75 , 1.0 , 2.0 , 3.0 , 4.0 , 6.0 , 8.0 , 12.0 h . The concentrations of levofloxacin lactate in plasma were determined and the pharmacokinetic parameters of two department model were calculated. RESULTS The main pharmacokinetic parameters of levofloxacin lactate t 1/2β 、AUC、Cl、V were not significantly different in rabbits by oral administration at 8∶00 and 12∶00. CONCLUSIONS The pharmacokinetics of levofloxacin lactate has no obvious change in circadian rhythms in rabbits.