中药脂肝宁对酒精加高脂饮食大鼠脂肪肝丙二醛、谷胱甘肽的影响

EFFECTS OF CHINESE HERBAL COMPOUND ZHIGANNING ON MALONDIALDEHYDE,GLUTATHIONE OF FATTY LIVER INDUCED BY HIGH FAT DIET AND ALCOHOL IN RATS

目的探讨自行研制中成药脂肝宁对脂肪肝的预防机理。方法以酒精加高脂饮食大鼠脂肪肝模型 ,对脂肝宁、来适可、熊去氧胆酸、强肝消脂口服液预防脂肪肝的作用进行对比研究 ,观察其病理学改变、脂质过氧化等方面的指标。结果经预防给药 ,脂肝宁大剂量、强肝消脂口服液和来适可均不同程度使血清和肝组织丙二醛降低、谷胱甘肽升高。结论脂肝宁能够抑制脂质过氧化反应 ,抑制血清及肝组织丙二醛升高 ,阻止谷胱甘肽耗竭 ,提高谷胱甘肽活性 。

ObjectiveTo evaluate the effects of Chinese herbal compound Zhiganning on fatty liver induced by high fat diet and alcohol in rats, and determine the possible mechanism. MethodsRat models of fatty liver were induced by high fat diet and alcohol. To compare the lipotropic effects of Zhiganning, Lescol, UDCA and Qiangganxiaozhi solution ,the histological changes in liver, malondialdehyde (MDA) and glutathione (GSH) in serum and liver were abserved. ResultsThe contents of MDA(both in serum and liver) in group of large dose Zhiganning solution were significantly lower than in model group, while the contents of GSH (in serum and liver)were significantly higher than that in model group (P< 0.05 ).ConclusionZhiganning can prevent liver cell from lipid peroxidation injury.