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噬菌体展示技术及其应用 被引量：1

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摘要 噬菌体展示实现了物质的遗传型与表现型之间的转化,便于人工操作。噬菌体展示技术几乎能展示所有分子的功能基团或其配体,在生物技术领域中有着非常广泛的应用价值。
作者 余传信 管晓红
机构地区 江苏省血吸虫病防治研究所 南京医科大学病原生物予寄生虫病教研室
出处 《国外医学（临床生物化学与检验学分册）》 2003年第4期215-217,共3页 Foreign Medical Sciences(section of Clinical Biochemistry and Laboratory Medicine
基金 国家自然科学基金(39900129)
关键词 噬菌体展示技术 原理 应用 遗传型 表现型
分类号 Q936 [生物学—微生物学]
  • 相关文献

参考文献14

  • 1余传信,朱荫昌,殷旭仁,何伟,许永良,管晓虹.用噬菌体肽库筛选SjC-TPI的模拟抗原表位[J].中国寄生虫学与寄生虫病杂志,2001,19(1):11-14. 被引量：15
  • 2Smith GP. Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface[J]. Science, 1985,228(4705) : 1315-1317.
  • 3Wang L, Hertzog P, Galanis M, et al. Structure-function analysis of human IFN-alpha:mapping of a conformational epitope by homologue scanning[J]. J Immunol, 1994,152(2) :705-715.
  • 4Folgori F,Tafi R,Meola A, et al. A general strategy to identify mimotopes of pathological antigens using only random peptide libraries and human sera[J]. Embo J,1994,13(9) :2236-2243.
  • 5Wu Y, Wan Y, Bian J. Phage display particles expressing tumor-specific antigens induce preventive and therapeutic anti-tumor immunity in murine p815 model [J]. Int J Cancer, 2002,98(5) : 748-753.
  • 6Ferrer M, Harrison SC. Peptide ligands to human immunodeficiency virus type 1 gp120 identified from phage display libraries[J]. J Virol, 1999,73(7) : 5795-5802.
  • 7Chen L,Sigler PB. The crystal structure of a GroEL/peptide complex: plasticity as a basis for substrate diversity[J]. Cell, 1999,99(7) : 757-768.
  • 8Dubaquié Y, Lowman HB. Total alanine-scanning mutagenesis of insulin-like growth factor-1 (IGF-1) identifies differential binding epitopes for IGFBP-1 and IGFBP-2[J]. Biochemistry, 1999,38(2) : 6386-6396.
  • 9Cloutier SM, Chagas JR, Math JP, et al. Substrate specificity of human kallikrein 2(hK2) as determined by phage display technology [J]. Eur J Biochem, 2002, 269(11) :2747-2754.
  • 10Dennis MS, Eigenbrot C, Skelton NJ, et al. Peptide exosite inhibitors of factor Ⅶ a as anticoagulants[J]. Nature,2000,404(6777) :465-470.

二级参考文献5

共引文献14

同被引文献18

  • 1[1]Smith GP. Filamentous fusion novel expression vectors that display cloned antigens on the virion surface[ J]. Science,1985,228:1315-1317.
  • 2[2]Geysen HM, Rodda SJ, Mason TJ. A prior delineation of a peptide which mimics a discontinuous antigenic determinant [ J ]. Mol Immunol,1986,23:709-715.
  • 3[4]Cabilly S. The basic structure of filamentous phage and its use in the display of combinatorial peptide libraries[J]. Mol Biotechnol,1999,12:143-148.
  • 4[7]Stephen F, Smith GP. Antibody-selectable filamentous fd phage vectors: affinity purification of target genes[ J]. Gene, 1988, 73:305-318.
  • 5[8]Folgori A, Tafi R, Meola A, et al. A general strategy to identify mimotopes of pathological antigen using only random peptide libraries and human sera[ J]. EMBO J, 1994,13:2235-2243.
  • 6[9]Malmborg AC, Soderlind E, Frost L, et al. Selective phage infection mediated by epitope expression on F pilus[ J]. J Mol Biol, 1997,273:544-551.
  • 7[13]Beghetto E, Pucci A, Minenkova O, et al. Identification of a human immunodominant B-cell epitope within the GRA1 antigen of Toxoplasma gondii by phage display of cDNA libraries[ J]. Int J Parasitol,2001,31:1659-1668.
  • 8[14]Beghetto E, Spadoni A, Buffolano W, et al. Molecular dissection of the human B-cell response against Toxoplasma gondii infection by lambda display of cDNA libraries[ J]. Int J Parasitol,2003 ,33 :163-173.
  • 9[16]Cristina MD, Porto PD, Buffolano W, et al. The Toxoplasma gondii bradyzoite antigens BAG1 and MAG1 induce early humoral and cell-mediated immune responses upon human infection [ J ]. Microbes and Infection,2004,6:164-171.
  • 10成军,钟彦伟,施双双,倪勤,夏小兵,董菁,王刚,刘友昭,王琳,刘妍,杨继珍,陈菊梅.乙型肝炎病毒表面抗原人源单链可变区抗体基因的克隆与鉴定[J].肝脏,2000,5(3):130-132. 被引量：15

引证文献1

国外医学（临床生物化学与检验学分册）
2003年 第4期

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