刺激颈交感神经对家兔心脏功能活动变化的影响

Influence of stimulating cervical sympathetic nerve on cardiac function in rabbits

目的 探讨颈椎性类冠心病时颈交感神经受累对心脏功能的影响。方法 健康家兔 30只 ,显露双侧颈上、颈下交感神经节及心下神经 ,对各部分逐一给以电刺激 ,采用生理多导仪分别记录刺激后不同时间点的心电图ST段 (Electroccardiogram ST ,ECG ST)、左心室内压 (LeftVentriclePressure,LVP)、左心室内压最大上升速率 (Developedpressure/Developedtimemax ,Dp/Dtmax)的变化情况。 结果 刺激颈上交感节后ECG ST、LVP、Dp/Dtmax均无变化 ;刺激颈下交感节和心下神经后LVP、Dp/Dtmax值明显下降 ,ECG出现明显的ST T改变。结论 下位颈椎病变可能更易刺激交感神经而出现心肌缺血性改变 。

Objective To study effects of stimulating cervical sympathetic nerve on cardiac function so as to explore mechanism of cervical coronary heart diseases Methods In 30 rabbits,bilateral superior cervical ganglion(SCG),inferior cervical ganglion(ICG)and inferior cervical cardiac nerve(ICCN)were exposed and stimulated separately by electricity.Changes of index of cardiac function,such as Left ventricle pressure(LVP),developed pressure/developed time max (Dp/Dt max)and ECG ST were recorded with physiologic instrument before and after stimulation.Results Stimulating SCG did not change LVP,Dp/Dt max and ECG ST( P >0 05).After stimulating ICG and ICCN,LVP and Dp/Dt max were descended obviously( P <0 01),besides ST segment and T wave depressed in ECG.With time,LVP,Dp/Dt max and ECG ST could ameliorate gradually.Conclusion Lesion occurred at inferior cervical vertebra was easy to stimulate sympathetic nerve,which could induce myocardial ischemia or abnormal cardiac contractility.