纳米卡拉胶微球的制备

Preparation of Carrageenan Microspheres

利用 Span 80作表面活性剂 ,正丁醇作助表面活性剂制得反相微乳液。将天然海洋高分子κ-卡拉胶进行酸水解使其分子量降低 ,通过反相乳液法对水解后的κ-卡拉胶进行分散并用甲醛和戊二醛进行交联 ,制备卡拉胶微球 ,利用 TEM、IR研究了卡拉胶微球的粒度和分子结构变化。 TEM显示 :低分子量的卡拉胶能够得到纳米级的卡拉胶微球 ,粒径约为 40 nm,添加正丁醇有助于卡拉胶的分散。 IR光谱证明了甲醛和戊二醛在卡拉胶微球内部发生了羟醛缩合反应 。

Microemulsifiable solution was obtained with Span 80 as a surfactant and n butanol as a cosurfactant. After acidichydrolysis, the solubility and viscosity of κ Carrageenan solution decreased. κ Carrageenan was dispersed into microspheres by the means of emulsion method. The radius and chemical structure of microspheres were characterized by TEM and XRD. TEM experiments showed that the particles was about 40 nm. The size distribution of κ Carrageenan was promoted by n butanol. IR spectra proved that microsphere was crosslinked by the reaction of methanal and glutaraldehyde with hydroxy of κ Carrageenan.