糖尿病中促动脉粥样硬化因素的探讨

Studies on the Factors Promoting Atherosclerosis in Diabetics

我们对64例糖尿病患者和20名正常人的糖代谢、脂代谢、血小板和血管内皮细胞前列腺素代谢的水平进行了临床观察。发现糖尿病患者载脂蛋白B、低密度脂蛋白胆固醇、总脂固醇、甘油三酯和血栓素B_2的浓度均有不同程度的升高,而载脂蛋白A_1、高密度脂蛋白胆固醇和6-酮前列腺素F_(1α)的浓度则下降。同时糖代谢异常与脂代谢紊乱、糖代谢异常与前列腺素代谢物水平、以及脂代谢紊乱与前列腺素代谢物水平之间均无明显关系。推想糖尿病中促动脉粥样硬化的各种高危因素可能从不同的角度作用于血管壁,促进动脉粥样硬化的发生和发展。

We made a clinical observation and investigation on the metabolism ofsugar,lipid,lipoproteins,apolipoproteins,prostaglandin,platelets and vascular endot-helial cells in 64 diabetics and 20 controls.The increase in the blood levels of apoB,LDL-C,Ch,TG and TXB2,but the decrease in the blood levels of ApoA1,HDL-C and6-keto-PGF1 alpha in diabetics were observed.There were no significant relationshipsbetween TXB2 or 6-keto-PGF1 alpha and TG,Ch,HDL-C,LDL-C,ApoA1 or ApoB,andthere was not any relationship between haemoglobin A1 or fasting blood glucose and TG,Ch,HDL-C,LDL-C,ApoA1,ApoB,TXB2 or 6-keto-PGF1 alpha in diabetics.We su-pposed that each risk factor promoting diabetic atherosclerosis may make its own effecton the vasculature in different ways.