不同时间应用大剂量地塞米松治疗外伤性脑水肿的实验研究

The Effect of Large Doses of Dexamethasone upon Traumatic Cerebral Edema Given in Different Periods-An Experimental Study

本文报道了不同时间应用大剂量地塞米松治疗外伤性脑水肿的实验研究,证明大剂量地塞米松对外伤性脑水肿有确定的疗效,且早期应用效果更好。同时,对激素所使用的时间、剂量和种类进行了讨论。

The effect of large doses of DXM given in different periods upon traumaticcerebral edema of rats was studied experimentally.The results showed that a massivedose of DXM would certainly effect on the traumatic cerebral edema both in the prophy-laxis and treatment of the malady.Moreover,DXM being given earlier in the periodwould yield more preferable results.Discussions about when DXM is given,how manydoses may be needed,which kind of corticoid is advisable to choose and what side-effectsmust be noticed are all given in this paper.