依达拉奉注射液联合单唾液酸四己糖神经节苷脂钠注射液治疗急性脑梗死的临床疗效

Effect of edaravone Injection and GM1 Ganglioside in treating acute cerebral infarction

目的探讨依达拉奉注射液联合单唾液酸四己糖神经节苷脂钠注射液治疗急性脑梗死的临床疗效。方法选取2014年1月—2015年7月南京医科大学附属苏州市立医院收治的急性脑梗死患者99例,根据用药方案不同分为观察组51例与对照组48例。对照组患者予以单唾液酸四己糖神经节苷脂钠注射液治疗,观察组患者在对照组基础上加用依达拉奉注射液治疗。观察两组患者临床疗效、日常生活能力及不良反应发生情况。结果观察组患者总有效率高于对照组,日常生活能力评分高于对照组,差异有统计学意义(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论依达拉奉注射液联合单唾液酸四己糖神经节苷脂钠注射液治疗急性脑梗死的临床疗效显著,可改善患者日常生活能力及神经功能,且不良反应少。

Objective To explore the effect of edaravone Injection and GM1 Ganglioside in treating acute cerebral in-farction. Methods A total of 99 patients with acute cerebral infarction were selected in Suzhou Municipal Hospital Affiliated to Nanjing Medical University from January 2014 to July 2015,according to the different regimens,they were divided into study group 51 cases and control group 48 cases. Control group were given GM1 Ganglioside treatment,study group were given edara-vone Injection treatment on the basis of control group. Clinical effect,activity of daily living score and incidence of adverse reac-tions between the two groups were compared. Results The total effective rate of study group was higher than that of control group(P < 0. 05),activity of daily living score of study group was higher than that of control group(P < 0. 05);incidence of adverse reactions showed no significant differences between the two groups(P > 0. 05). Conclusion Edaravone Injection and GM1 Ganglioside have notable curative effect in the treatment of acute cerebral infarction,can improve the patients' daily life a-bility and nerve function,have less adverse reaction.