三联与四联用药治疗幽门螺杆菌感染儿童消化性溃疡的临床疗效对比

Comparison of effect between triple and quadruple therapy in treating children peptic ulcer with Hp infection

目的比较三联与四联用药治疗幽门螺杆菌(Hp)感染儿童消化性溃疡的临床疗效。方法选取2013—2014年合江县人民医院收治的Hp感染消化性溃疡患儿82例,根据入院先后分为三联组40例和四联组42例。三联组给予三联疗法,四联组给予四联疗法。比较两组Hp根除情况、临床疗效、不良反应发生情况及复发情况。结果两组Hp根治率、总有效率、不良反应发生率、复发率比较,差异无统计学意义(P>0.05),四联组复发时间晚于三联组,差异有统计学意义(P<0.05)。结论三联药物方案治疗Hp阳性儿童消化溃疡和含铋剂的四联方案疗效相当,临床治疗时应从儿童用药的安全性出发,优先考虑三联方案。

Objective To compare the effect between triple and quadruple therapy in treating children peptic ulcer with Hp infection. Methods A total of 82 children with peptic ulcer with Hp infection were selected in the People's Hospital of Hejiang County from 2013 to 2014,according to hospital admissions,they were divided into triple group 40 cases and quadruple group 42 cases. Triple group were given triple therapy treatment,quadruple group were given quadruple therapy treatment. Hp e-radication situation,clinical effect,incidence condition of adverse reaction and recurrence were observed between the two groups were compared. Results Hp radical rate,the total effective rate,incidence of adverse reactions and recurrence rate showed no significant differences between the two groups(P > 0. 05);recurrence time of quadruplet group was later than that of triple group(P < 0. 05). Conclusion Hp positive children peptic ulcer and triple drug regimen for quad treatment solution contai-ning bismuth agent,medicine for children from the safety of clinical treatment,give priority to the joint program.