TUR-Bt术后不同溶剂配制吡柔比星行膀胱灌注不良反应情况的对照研究

Comparative study of adverse reactions in using different solvents in preparation of pirarubicin for bladder irrigation after TUR-Bt

目的探讨0.9%氯化钠溶液(NS)和5%葡萄糖溶液(GS)配制吡柔比星(THP)在经尿道膀胱肿瘤电切术(TUR-Bt)后膀胱灌注的不良反应。方法选取2011年6月—2013年6月双流县第一人民医院收治的浅表性膀胱尿路上皮癌患者60例,随机分为NS组和GS组,各30例。NS组给予THP 40mg+NS 40ml;GS组给予THP 40mg+GS 40ml。观察两组不良反应并随访。结果 GS组不良反应发生率低于NS组,差异有统计学意义(P<0.05)。结论 GS配制THP在TUR-Bt后膀胱灌注对于预防浅表性膀胱尿路上皮癌术后复发有良好的临床疗效,且不良反应更少。

Objective To investigate the adverse reaction of using physiological saline( 0. 9% NS) and 5% glucose( GS) in preparation of pirarubicin( THP) for bladder irrigation after transurethral resection of bladder tumor( TUR- Bt).Methods A total of 60 bladder urothelial carcinoma paitents after TUR- Bt in the First People’s Hospital of Shuangliu County from June 2011 to June 2013 were selected, they were randomly divided into NS group and GS group,30 cases in each group. NS group were given THP 40 mg + NS 40 ml,GS group were given THP 40 mg + GS 40 ml. Adverse reaction of two groups were observed and patients were followed- up. Results Adverse reaction rate of GS group was lower than NS group( P <0. 05). Conclusion The efficacy of both using 0. 9% NS and 5% glucose in preparation pirarubicin for bladder irrigation after TUR- Bt is good,however 0. 9% NS may cause significant bladder irritation and bladder superficial ulcer.