硫普罗宁联合甘草酸二铵注射液治疗慢性病毒性乙型肝炎的临床疗效

Effect of tiopronin and diammonium glycyrrhizinate injection in treating chronic severe hepatitis B

目的探讨硫普罗宁联合甘草酸二铵注射液治疗慢性病毒性乙型肝炎的临床疗效。方法选取2013年12月—2015年1月广西南宁市邕宁区人民医院收治的慢性病毒性乙型肝炎患者140例,按照住院先后顺序分为治疗组与对照组,各70例。对照组患者予以甘草酸二铵注射液治疗,治疗组患者在对照组基础上加用硫普罗宁治疗。观察两组患者治疗15、30d肝功能指标复常率(血清丙氨酸氨基转移酶复常率、胆红素复常率)、乙肝标志物〔乙肝病毒脱氧核糖核酸(HBV-DNA)、乙肝病毒e抗原(HBe Ag)、乙肝表面抗原(HBs Ag)〕转阴情况、临床疗效及不良反应发生情况。结果治疗15d两组患者血清丙氨酸氨基转移酶复常率、胆红素复常率比较,差异无统计学意义(P>0.05);治疗30d治疗组血清丙氨酸氨基转移酶复常率、胆红素复常率高于对照组,差异有统计学意义(P<0.05)。两组患者HBV-DNA、HBe Ag、HBs Ag转阴率比较,差异无统计学意义(P>0.05)。治疗组患者总有效率高于对照组,差异有统计学意义(P<0.05)。两组患者均未发生严重不良反应。结论硫普罗宁联合甘草酸二铵注射液治疗慢性病毒性乙型肝炎的临床疗效显著,可改善患者临床症状,且不良反应少。

Objective To explore the effect of tiopronin and diammonium glycyrrhizinate injection in treating chronic severe hepatitis B. Methods A total of 140 patients with chronic severe hepatitis B were selected in the People’ s Hospital Yongning District,Nanning City in Guangxi from December 2013 to January 2015,according to the order in hospital,they were divided into treatment group and control group,70 cases in each group. Control group were given diammonium glycyrrhizinate injection treatment,treatment group were given tiopronin treatmenton on the basis of control group. After 15,30 days of treatment,normalization for liver function parameters( normalization for serum alanine aminotransferase,normalization for bilirubin),hepatitis B markers 〔HBV- DNA,hepatitis B e antigen( HBe Ag),hepatitis B surface antigen( HBs Ag) 〕 became negative,clinical effect and incidence of adverse reactions between the two groups were compared. Results After 15 days of treatment,normalization for serum alanine aminotransferase,normalization for bilirubin showed no significant differences between the two groups( P > 0. 05); after 30 days of treatment,normalization for serum alanine aminotransferase,normalization for bilirubin showed significant differences between the two groups( P < 0. 05). Negative rate of HBV- DNA,HBe Ag,HBs Ag showed no significant differences between the two groups( P > 0. 05). The total effective rate of treatment group was higher than that of control group( P < 0. 05). No one of the two groups occurred serious adverse reactions. Conclusion Tiopronin and diammonium glycyrrhizinate injection have notable curative effect in the treatment of chronic severe hepatitis B,can improve the clinical symptoms and have less adverse reaction.