沙美特罗替卡松联合噻托溴铵粉吸入剂治疗重度、极重度慢性阻塞性肺疾病稳定期患者的临床疗效

Effect of salmeterol fluticasone propionate combined with tiotropium bromide powder for inhalation in treating severe and very severe stable chronic obstructive pulmonary disease patients

目的探讨沙美特罗替卡松联合噻托溴铵粉吸入剂治疗重度、极重度慢性阻塞性肺疾病(COPD)稳定期患者的临床疗效。方法选取2013年2月—2015年1月双流县第一人民医院收治的重度、极重度COPD稳定期患者100例,随机分为研究组与对照组,各50例。对照组患者予以沙美特罗替卡松治疗,研究组患者在对照组基础上加用噻托溴铵粉吸入剂治疗。观察两组患者临床疗效、治疗前后6min步行距离及不良反应发生情况。结果研究组患者总有效率高于对照组,差异有统计学意义(P<0.05);治疗前两组患者6min步行距离比较,差异无统计学意义(P>0.05),治疗后研究组患6min步行距离长于对照组,差异有统计学意义(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论沙美特罗替卡松联合噻托溴铵粉吸入剂治疗重度、极重度COPD稳定期患者的临床疗效显著,可改善患者临床症状,且不良反应少。

Objective To explore the effect of salmeterol fluticasone propionate combined with tiotropium bromide powder for inhalation in treating severe and very severe stable chronic obstructive pulmonary disease( COPD) patients. Methods A total of 100 patients with severe and very severe stable COPD were selected in the First People’ s Hospital of Shuangliu County from February 2013 to January 2015,they were randomly divided into study group and control group,50 cases in each group. Control group were given salmeterol fluticasone propionate treatment,study group were given tiotropium bromide powder for inhalation treatment on the basis of control group. Clinical effect,before and after treatment 6- minute walking distance and incidence condition of adverse reaction were compared between the two groups. Results The total effective rate of study group was higher than that of control group( P < 0. 05); before treatment,6- minute walking distance showed no significant differences between the two groups( P > 0. 05),after treatment,6- minute walking distance of study group was longer than that of control group( P < 0. 05); incidence of adverse reactions showed no significant differences between the two groups( P >0. 05). Conclusion Salmeterol fluticasone propionate combined with tiotropium bromide powder for inhalation have notable curative effect in the treatment of severe and very severe stable COPD patients,can improve the clinical symptoms and has less adverse reaction.