摘要
目的分析不同病变程度冠状动脉粥样硬化性心脏病(冠心病)患者血浆Chemerin水平的变化特点。方法随机选择经冠状动脉造影(CAG)确诊的冠心病患者166例作为冠心病组,根据CAG结果中显示的冠脉病变支数又将冠心病组分为单支病变亚组55例,双支病变亚组70例,多支病变亚组41例。另选择CAG未见冠脉狭窄的患者30例作为非冠心病组。监测各组患者血浆Chemerin水平,比较冠心病患者与非冠心病患者以及冠脉病变程度不同亚组患者血浆Chemerin水平差异。结果冠心病各亚组血浆Chemerin水平均高于非冠心病组,差异均有统计学意义(P<0.05)。冠脉不同病变程度亚组间,随着冠脉病变支数的增加,血浆Chemerin水平逐渐增高,差异均有统计学意义(P<0.05)。结论血浆Chemerin水平在一定程度上可以预测冠心病以及冠脉病变程度。
Objective To explore the relationship between plasma chemerin level and the severity of coronary lesions in patients with coronary heart disease( CHD). Methods Based on the results of coronary angiography,166 patients with diagnosed CHD were randomly divided into different groups according to coronary artery lesion counts,including single-vessel lesions in 55 cases,double-vessel lesions in 70 cases and triple-vessel lesions in 41 cases. Another 30 people in whom non coronary stenosis were selected as non-CHD group. Plasma chemerin level were detected by ELISA. Results Plasma chemerin level in CHD group were significantly higher than that in non-CHD group( P < 0. 05). Correlation analysis of plasma chemerin level and the severity of coronary lesions showed the differences between different groups were statistically significant( P < 0. 05).With the increase of coronary stenosis counts,the plasma chemerin level was gradually rised( P < 0. 05). Conclusion Plasma chemerin level is a role in early warning for CHD and the severity of coronary lesions.
出处
《临床合理用药杂志》
2016年第10期15-16,共2页
Chinese Journal of Clinical Rational Drug Use
