利巴韦林注射液联合痰热清超声雾化治疗流感病毒感染致病毒性肺炎的临床疗效

Clinical efficacy of ribavirin injection combined with tanreqing ultrasonic atomizing in the treatment of influenza virus infection pathogenic viral pneumonia

目的探讨利巴韦林注射液联合痰热清超声雾化治疗流感病毒感染致病毒性肺炎的临床疗效。方法选择2012—2014年湖北省中西医结合医院收治的67例流感病毒感染致病毒性肺炎患者,随机分为观察组34例和对照组33例。观察组采用利巴韦林注射液联合痰热清超声雾化治疗,对照组采用利巴韦林注射液治疗,两组疗程均为2周。比较两组患者临床症状(咳嗽、喘息、发热、全身酸痛等)好转时间,酶学指标恢复正常时间,肺部病灶吸收时间,动脉血气分析指标(Pa O2及SPO2)及不良反应发生情况。结果观察组患者咳嗽、喘息、发热、全身酸痛好转时间短于对照组,酶学指标恢复正常时间、肺部病灶吸收时间短于对照组,总有效率高于对照组,差异有统计学意义(P<0.05)。观察组患者治疗后第3天,第7天Pa O2、SPO2高于对照组,差异有统计学意义(P<0.05)。两组患者治疗期间均未发生明显不良反应。结论利巴韦林注射液联合痰热清超声雾化治疗流感病毒感染致病毒性肺炎的临床疗效显著,可有效改善患者临床症状,不良反应少。

Objective To investigate the clinical efficacy of ribavirin injection combined with tanreqing ultrasonic atomizing in the treatment of influenza virus infection pathogenic viral pneumonia. Methods A total of 67 patients with influenza virus infection pathogenic viral pneumonia were selected from 2012 to 2014 in the Integrative Medicine Hospital in Hubei Province,which were randomly divided into the observation group( n = 34) and the control group( n = 33). The observation group was treated with ribavirin injection combined with tanreqing ultrasonic nebulizer,the control group was treated with ribavirin injection,two weeks as a course of treatment. The clinical symptoms( cough, wheezing, fever, body aches, etc) improved time,liver enzyme recovery time,pulmonary lesions absorption time,arterial blood gas analysis( Pa O2 and SPO2) and adverse events were observed. Results The improving time of cough,wheezing,fever,body aches of observation group were shorter than the control group,the total effective rate was higher than control group( P < 0. 05),the Pa O2 and SPO2of the observation group were higher than the control group in the 3 days and 7 days after treatment( P < 0. 05). No significant adverse reactions occurred during the treatment between the two groups. Conclusion It has an obviously clinical efficacy of the ribavirin injection combined with tanreqing ultrasonic atomizing in the treatment of influenza virus infection pathogenic viral pneumonia,it can effectively improve the clinical symptoms,and make fewer adverse reactions.