纤维支气管镜检查前吸入沙丁胺醇的临床效果观察

Clinical effect of fiberoptic bronchoscopy before inhalation of salbutamol

目的探讨术前吸入沙丁胺醇对纤维支气管镜检查的影响。方法将需行纤维支气管镜检查患者100例随机分为沙丁胺醇吸入组和对照组各50例。沙丁胺醇吸入组于镜检前雾化吸入沙丁胺醇,对照组不吸入沙丁胺醇。比较2组患者的一般情况、血液动力学及不良事件发生情况。结果手术前(T0)、雾化吸入沙丁胺醇后(T1)和麻醉后入镜前(T2)时2组患者血流动力学指标差异无统计学意义(P>0.05);纤维支气管镜入声门前(T3)、手术进行30秒后(T4)和退镜后即刻(T5)时沙丁胺醇吸入组患者MAP和HR低于对照组,在T4和T5时点沙丁胺醇吸入组患者Sp O2高于对照组患者;沙丁胺醇吸入组患者供氧不良、高血压、心动过速、体动、气道痉挛、呛咳、咽喉痛的发生率低于对照组;沙丁胺醇吸入组患者检查时间、苏醒时间均短于对照组,麻醉药物丙泊酚和瑞芬太尼的用量均少于对照组,差异均有统计学意义(P<0.05)。结论纤维支气管镜检查患者术前吸入沙丁胺醇能降低患者并发症的发生率。

Objective To explore the effect of fiberoptic bronchoscopy before inhalation of salbutamol. Methods 100 patients undergoing fiberoptic bronchoscopy were randomly divided into salbutamol group and control group,each of 50 ca-ses. Salbutamol group inhaled salbutamol before microscopic examination. Control group patients did not receive salbutamol. And then the general conditions,hemodynamic and adverse events were compared between the two groups. Results The hemo-dynamics index of two groups(T0 ,T1 ,T2 )was no significant difference(P ﹥ 0. 05);Salbutamol group group had a lower MAP and HR(T3 ,T4 and T5 )compared with control group,and a higher SpO2 compared with control group(T4 ,T5 ). Also,less ad-verse events also found in salbutamol group,including poor oxygen,high blood pressure,tachycardia,body movement,airway spasm,cough,sore throat. In addition,the patient in salbutamol group group had a shorter examination and recovery time with less propofol and remifentanil(P ﹤ 0. 05). Conclusion Inhalation salbutamol before fiberoptic bronchoscopy could reduce the incidence of the complications.