垂体后叶素联合酚妥拉明治疗支气管扩张大咯血的有效性及安全性研究

Efficacy and safety of pituitrin combined phentolamine on bronchiectasis with massive hemoptysis

目的探讨垂体后叶素联合酚妥拉明治疗支气管扩张大咯血的有效性及安全性。方法选取山西省原平市第一人民医院2012年8月—2015年8月收治的支气管扩张大咯血患者80例,按照随机数字表法分为对照组和试验组,各40例。对照组仅采用垂体后叶素治疗,试验组在对照组基础上联合酚妥拉明治疗。比较两组患者的治疗效果及不良反应发生情况。结果治疗后,试验组治疗总有效率高于对照组,差异有统计学意义(χ2=8.51,P<0.05);试验组不良反应发生率低于对照组,差异有统计学意义(χ2=4.31,P<0.05)。结论垂体后叶素联合酚妥拉明治疗支气管扩张大咯血疗效显著,且不良反应少,值得临床推广应用。

Objective To investigate the efficacy and safety of pituitrin combined phentolamine on bronchiectasis with massive hemoptysis. Methods A total 80 patients with bronchiectasis and massive hemoptysis were selected from August 2012 to August 2015 in the First People’s Hospital of Yuanping,Which were divided into the control group and the experiment group by random number table method,40 cases in each group. The control group was treated by pituitrin,the experiment group was treated by pituitrin combined phentolamine. The therapeutic effect and adverse reactions were compared. Results After treatment,the experiment group of effective rate was higher than control group,there was statistically significant( χ2= 8. 51,P <0. 05); the adverse reactions rate of experiment group was lower than control group,the difference was statistically significant( χ2= 4. 31,P < 0. 05). Conclusion it have an obviously clinical effect of pituitrin combined with phentolamine in the treatment of bronchiectasis with massive hemoptysis,the adverse reactions are less,it is worthy of clinical popularization and application.