奥曲肽联合普萘洛尔治疗肝硬化上消化道出血的临床疗效研究

Clinical efficacy of octreotide combined with propranolol in the treatment of cirrhotic upper gastrointestinal bleeding

目的探讨奥曲肽联合普萘洛尔治疗肝硬化上消化道出血的临床疗效。方法选取2013年12月—2015年12月横县人民医院收治的肝硬化上消化道出血患者120例,随机分为研究组与对照组,各60例。研究组给予奥曲肽联合普萘洛尔治疗,对照组给予奥曲肽治疗。观察两组患者临床疗效、止血时间、心率、中心静脉压、再出血发生率及不良反应发生率。结果研究组患者总有效率高于对照组,差异有统计学意义(P<0.05)。研究组止血时间短于对照组,心率低于对照组,中心静脉压高于对照组,差异有统计学意义(P<0.05)。研究组再出血发生率、不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论奥曲肽联合普萘洛尔治疗肝硬化上消化道出血的临床疗效确切,能有效缩短止血时间,降低再出血发生率及不良反应发生率。

Objective To discuss the clinical efficacy of octreotide combined with propranolol in the treatment of cirrhotic upper gastrointestinal bleeding. Methods A total of 120 cases of patients with cirrhotic upper gastrointestinal bleeding were selected from December 2015 to December 2013 in Heng County People’s Hospital,which were randomly divided into the study group and the control group,60 cases in each group. The study group was treated by octreotide combined with propranolol,the control group was treated by octreotide. The clinical efficacy,hemostatic time,heart rate,Central venous pressure,recurrent bleeding rate and incidence of adverse reactions were observed. Results The total effective rate of the study group was higher of the study group than that of the control group,the difference was statistically significant( P < 0. 05). Of the study group,the hemostatic time was shorter than control group,the heart rate was lower than those of control group,central venous pressure was higher than those of control group,the differences were statistically significant( P < 0. 05). The rebleeding rate and incidence of adverse reactions of the study group were lower than those of control group,the differences were significant( P< 0. 05). Conclusion It has a obvious efficacy of the octreotide combined with propranolol in the treatment of cirrhotic upper gastrointestinal bleeding,and can effectively shorten hemostatic time,reduce the rebleeding rate and incidence of adverse reactions.