氨溴索治疗慢性阻塞性肺疾病的临床疗效及其对肺功能的影响

Clinical effect of ambroxol in treating chronic obstructive pulmonary disease and the impact for pulmonary function

目的研究氨溴索治疗慢性阻塞性肺疾病(COPD)的临床疗效及其肺功能改变情况。方法选取成都市龙泉驿区第一人民医院2012年2月—2014年2月收治的COPD患者120例,分为对照组与观察组,各60例。对照组患者给予常规治疗,观察组在对照组基础上给予氨溴索注射液治疗,比较两组的临床疗效、肺功能指标变化情况及不良反应发生情况。结果观察组治疗总有效率高于对照组,第1秒用力呼气容积(FEV1)、用力肺活量(FVC)及FEV1/FVC高于对照组,差异有统计学意义(P<0.05)。两组患者均未发生不良反应。结论氨溴索治疗COPD可显著提高临床疗效,还可有效改善患者肺功能,安全可靠。

Objective To study the clinical effect of ambroxol in treating chronic obstructive pulmonary disease and the impact for pulmonary function. Methods A total of 120 patients with COPD were selected from February 2012 to February2014 in the First People’ s Hospital of Chengdu Longquan Post Area,which were divided into control group and observation group,60 cases in each group,the control group was treated with conventional therapy,observation group was given ambroxol treatment on the basis of control group. The clinical efficacy,pulmonary function and adverse reactions between two groups were compared. Results The total effective rate of observation group was higher than control group,the FEV1、FVC and FEV1/FVC of observation group were higher than control group,the differences were statistically significant( P < 0. 05). There was no adverse reactions occurred. Conclusion Ambroxol can improve the curative effect in treating COPD,can effectively improve the pulmonary function.