紫杉醇联合阿霉素治疗局部晚期乳腺癌的临床效果研究

Clinical effect of paclitaxel combined with doxorubicin in treating locally advanced breast cancer

目的研究紫杉醇联合阿霉素治疗局部晚期乳腺癌的临床效果。方法选取广西梧州市工人医院2008—2015年收治的局部晚期乳腺癌患者110例,按照随机数字表法分为A组和B组,每组55例。A组患者给予紫杉醇联合阿霉素治疗,B组患者给予卡培他滨联合阿霉素治疗。比较两组患者的临床效果及毒副作用发生情况。结果A组患者治疗总有效率高于B组,差异有统计学意义(P<0.05)。两组患者治疗后毒副作用发生率比较,差异无统计学意义(P>0.05)。结论紫杉醇联合阿霉素治疗局部晚期乳腺癌疗效显著,毒副作用少。

Objective To study the clinical effect of paclitaxel combined with adriamycin in treating locally advanced breast cancer. Methods A total of 110 patients with locally advanced breast cancer were selected from 2008 to 2015 in Wuzhou Worker’s Hospital,which were divided into A group and B group according to the random number table method,55 cases in each group. A group was given paclitaxel combined with doxorubicin,B group was given capecitabine combined with doxorubicin. The clinical effect and toxic and side effects of two groups were compared. Results The total effective rate of A group was higher than B group,the difference was statistically significant( P < 0. 05). There was no statistically significant differences in the incidence of toxic and side effects after treatment between the two groups( P > 0. 05). Conclusion Paclitaxel combined with doxorubicin has significant effect on locally advanced breast cancer,and has less toxic and side effects.