氨氯地平联合替米沙坦基础上加用复方阿米洛利治疗原发性高血压伴左心室肥厚的效果研究

Effect of amiloride compound on the basis of amlodipine and telmisartan in treating hypertensive disease and the reversing left ventricle function

目的探讨氨氯地平联合替米沙坦基础上加用复方阿米洛利治疗原发性高血压伴左心室肥厚(LVH)的效果。方法选取河北冶建医院2014年6月—2015年12月收治的原发性高血压伴LVH患者134例,根据随机数字表法分为对照组(n=69)和观察组(n=65)。对照组口服氨氯地平和替米沙坦治疗,观察组在对照组基础上加服复方阿米洛利治疗,2个月后观察两组患者的降压效果及LVH情况。结果治疗前,两组患者的收缩压、舒张压、室间隔厚度(IVST)、左心室后壁厚度(LVPWT)、左心室舒张末期内径(LVEDd)及左心室重量指数(LVMI)比较,差异无统计学意义(P>0.05);治疗后,观察组收缩压、舒张压、IVST、LVPWT、LVMI低于对照组,差异有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论在氨氯地平及替米沙坦的基础上加用复方阿米洛利治疗原发性高血压伴LVH效果显著,可进一步降低血压,并且能显著改善LVH。

Objective To discuss the effect of amiloride compound on the basis of amlodipine and telmisartan in treating primary hypertensive associated with LVH. Methods A total of 134 cases of patients with primary hypertensive associated with LVH were selected from June 2014 to December 2015 in the Hebei Building’ s Hospital,which were divided into control group( n = 69) and observation group( n = 65). The control group was given amlodipine and telmisartan,the observation group was given amiloride compound on the basis of control group,the antihypertensive efficacy and LVH were observed between two groups after two months. Results Before treatment,there was no statisticalhy significant differences in SBP,DBP,IVST,LVPWT,LVEDd or LVMI between the two groups( P > 0. 05); after treatment,the SBP,DBP,IVST,LVPWT and LVMI of observation group were lower than control group,the differences were statisticalhy significant( P < 0. 05). There was no statisticalhy significant difference in adverse reaction rate between two groups( P > 0. 05). Conclusion Amiloride compound on the basis of amlodipine and telmisartan have an obvious effect in treating primary hypertensive associated with LVH,can further lower blood pressure,and can significantly improve LVH.