双歧杆菌联合柳氮磺胺吡啶对溃疡型结肠炎患者炎性递质的影响

Influence of bifidobacterium combined with salicylazosulfapyridine in the treatment of ulcerative colitis patients of inflammatory mediators

目的研究双歧杆菌联合柳氮磺胺吡啶对溃疡型结肠炎患者炎性递质的影响。方法选择河南省长葛市人民医院2014年11月—2015年10月收治的溃疡型结肠炎患者108例,按照随机数字表法分为对照组和治疗组,各54例。对照组仅采用柳氮磺胺吡啶治疗,治疗组采用双歧杆菌联合柳氮磺胺吡啶治疗,观察比较两组患者肠道菌群变化、血清炎性递质变化、超氧化物歧化酶(SOD)及丙二醛(MDA)水平及不良反应发生情况。结果治疗组患者肠球菌、乳酸杆菌、双歧杆菌值高于对照组,差异有统计学意义(P<0.05);治疗组血清及肠黏膜中肿瘤坏死因子α(TNF-α)、白介素6(IL-6)、MDA均低于对照组,白介素10(IL-10)、SOD均高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论双歧杆菌联合柳氮磺胺吡啶治疗溃疡型结肠炎疗效显著,能有效抑制炎性反应,提高治疗效果,减轻患者痛苦,可作为临床治疗溃疡型结肠炎的首选方法。

Objective To study the influence of bifidobacterium combined with salicylazosulfapyridine in the treatment of ulcerative colitis patients of inflammatory mediators. Methods A total of 108 cases of patients with ulcerative colitis were selected from November 2014 to October 2015 in the People’ s Hospital of Changge,which were divided into the control group and the treatment group according to random number table,54 cases in each group. While the control group was only received salicylazosulfapyridine treatment,the treatment group was received bifidobacterium combined with salicylazosulfapyridine treatment,the intestinal flora,serum inflammatory mediators,SOD and MDA levels and adverse reactions between the two groups were compared. Results The enterococcus,lactobacillus and bifidobacterium value of the treatment group were higher than those of the control group,the differences were statistically significant( P < 0. 05); the TNF- α,IL- 6 and MDA in serum and intestinal mucosa of the treatment group were lower than control group,the IL- 10,SOD were higher than those of control group,the differences were statistically significant( P < 0. 05); there was no statistically significant difference in adverse reaction rate between the two groups( P > 0. 05). Conclusion It has significantly clinical effect of bifidobacterium combined with salicylazosulfapyridine in the treatment of ulcerative colitis,it can effectively inhibit the inflammatory reactions,improve the treatment effect,reduce the pain of patients,and can be used as the preferred method of clinical treatment of ulcerative colitis.