持续气道正压通气对阻塞性睡眠呼吸暂停综合征患者氧化应激的影响

Effects of continuous positive airway pressure ventilation on oxidative stress in patients with obstructive sleep apnea syndrome

目的观察持续气道正压通气对阻塞性睡眠呼吸暂停综合征(OSAHS)患者氧化应激的影响。方法选择120例中、重度持续气道通气OSAHS患者作为观察组,另外选择同期于该院进行体检的120例健康者作为对照组。对观察组患者治疗前后及对照组进行睡眠监测,主要包括睡眠呼吸紊乱指数(AHI)、最低血氧饱和度(Sa O2)以及睡眠呼吸暂停最长时间;检测观察组治疗前后及对照组的空腹静脉血超氧化物歧化酶(SOD)、硫氧还蛋白-1(TRX-1)以及丙二醛(MDA)水平并进行了对比分析。结果治疗后,观察组AHI、最长呼吸暂停时间、MDA及TRX-1水平均明显小于治疗前(P<0.05),夜间Sa O2、SOD水平均明显大于治疗前(P<0.05),且患者组治疗后上述指标水平与对照组相比,差异均无统计学意义(P>0.05)。结论 OSAHS是一种氧化应激性疾病,尽早持续气道正压通气会显著改善OSAHS患者氧化应激指标水平,从而逆转氧化应激反应。

Objective To observe the effect of continuous positive airway pressure ventilation on oxidative stress in patients with obstructive sleep apnea syndrome( OSAHS). Methods 120 patients with medium and severe OSAHS continuous airway ventilation as observation group. In addition,120 healthy persons in hospital for physical examination were selected as control group. The apnea hypopnea index( AHI),the lowest oxygen saturation( Sa O2) and sleep apnea,the longest time,fasting venous blood superoxide dismutase( SOD),thioredoxin-1( TRX-1) and malondialdehyde( MDA) levels of observation group and control group were detected and analyzed. Results After treatment,the AHI,the longest time of apnea,MDA and TRX-1 levels of observation group were significantly less than before( P < 0. 05),the level of Sa O2 and SOD at night were significantly higher than before( P < 0. 05),and after treatment,the differences of the above index between the two groups were not statistically significant( P > 0. 05). Conclusion OSAHS is a kind of oxidative stress disease,and continuous positive airway pressure can significantly improve the level of oxidative stress in OSAHS patients.