摘要
目的观察阿仑膦酸钠对于治疗绝经后骨质疏松症患者的疗效及不良反应。方法随机选取绝经后骨质疏松症患者90例,将其分为试验组46例和对照组44例。试验组给予阿仑膦酸钠,对照组给予钙片。治疗6个月后,对比观察2组患者的临床疗效、骨密度变化及不良反应。结果试验治疗总有效率为91.3%高于对照组的84.1%,差异有统计学意义(P<0.05)。2组患者治疗后的骨密度较治疗前均有所增加,差异具有统计学意义(P<0.05);且试验组骨密度较对照组增加的更显著,差异具有统计学意义(P<0.05)。2组不良反应发生率差异无统计学意义(P>0.05)。结论阿仑膦酸钠治疗绝经后骨质疏松症疗效显著,值得在临床上推广应用。
Objective To investigate the clinical effect and adverse reaction of alendronate in the treatment of postmenopausal osteoporosis. Methods 90 patients with postmenopausal method were randomly divided into experimental group( 46cases) and control group( 44 cases). The experimental group were given alendronate sodium,the control group was given calcium. After 6 months of treatment,the clinical efficacy,changes of bone density and adverse reactions between the two groups were compared. Results The total effective rate of the experimental treatment( 91. 3%) was higher than that of the control group( 84. 1%),the difference was statistically significant( P < 0. 05). After treatment,the bone mineral density of the two groups were increased than before treatment,the difference was statistically significant( P < 0. 05); and the bone density of experimental group was significantly higher than that of the control group( P < 0. 05). There was no significant difference in the incidence of adverse reactions between the two groups( P > 0. 05). Conclusion The clinical effect of alendronate in the treatment of postmenopausal osteoporosis is significant,and the adverse reaction is less,and it is worth to be popularized in clinical application.
出处
《临床合理用药杂志》
2016年第19期54-55,共2页
Chinese Journal of Clinical Rational Drug Use