艾司洛尔在冠心病心肌缺血治疗中的应用效果

The application effect of esmolol in treating myocardial ischemia of coronary heart disease

目的探讨艾司洛尔在冠心病心肌缺血治疗中的应用效果。方法选取2010年10月—2015年9月宜春市第二人民医院治疗的冠心病心肌缺血患者140例,随机分为对照组与试验组,各70例。对照组给予抗血小板、抗凝、抗血栓药物阿司匹林、钙离子拮抗剂、他汀类等常规药物治疗。试验组在对照组基础上加用盐酸艾司洛尔注射液治疗。比较两组患者的症状评分、心电图ST段压低、心率、血压、治疗结果及不良反应发生情况。结果试验组症状评分、心电图ST段压低、血压低于对照组,差异有统计学意义(P<0.05);两组患者心率比较,差异无统计学意义(P>0.05)。试验组总有效率高于对照组,差异有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论艾司洛尔在冠心病心肌缺血治疗中的应用效果显著,可有效缓冠心病病变引起的心肌缺血,且不良反应少。

Objective To investigate the effect of esmolol in treating myocardial ischemia of coronary heart disease.Methods A total of 140 patients with myocardial ischemia of coronary heart disease were selected from October 2010 to September 2015 in the Second People's Hospital of Yichun,which were randomly divided into the control group and the experimental group,70 cases in each group. Patients in control group were given antiplatelet,anticoagulation,aspirin antithrombotic drugs,calciumion antagonist,statin and other routine drug therapy. Experimental group were given esmolol hydrochloride injection on the basis of control group. Symptom scores,ECG ST segment depression,heart rate,blood pressure,effect and adverse reactions were compared between the two groups. Results In experimental group,the symptoms scores,ECG ST segment depression,blood pressure were lower than the control group( P < 0. 05); heart rate between the two groups showed no significant differences( P > 0. 05). Total effective rate of experimental group was higher than that of the control group( P < 0. 05). The rate of adverse reactions between the two groups showed no significant differences( P > 0. 05). Conclusion Esmolol has significant effect in treating myocardial ischemia of coronary heart disease,can effectively delay the myocardial ischemia caused by coronary heart disease,and has less adverse reactions.