异位妊娠输卵管切除术对卵巢储备功能的影响

Influence of ectopic pregnancy with fallopian tube resection on ovarian reserve function

目的观察异位妊娠输卵管切除术对卵巢储备功能的影响。方法将120例异位妊娠患者作为试验组,其中试验A组60例采用保守治疗,试验B组60例采用输卵管切除术,另选取健康女性60例作为对照组,对比各组术前、术后1个月、术后3个月抗苗勒管激素(AMH)、卵泡刺激素(FSH)、黄体生成素(LH)、孕酮(P)、雌二醇(E2)水平。结果试验A组治疗前、治疗1个月、3个月AMH、FSH、LH、P及E2水平与对照组比较差异无统计学意义(P>0.05);与对照组、试验A组同时期及试验B组术前相比,试验B组治疗1个月、3个月后AMH、E2水平显著降低,FSH显著升高,差异均有统计学意义(P<0.01)。结论异位妊娠患者输卵管切除术后卵巢储备功能降低,有生育要求的育龄妇女尽量避免输卵管切除,尽可能采取药物等保守治疗,以保护卵巢功能。

Objective To discuss the clinical influence of fallopian tube resection on ovarian reserve function in patients with ectopic pregnancy. Methods 120 patients with ectopic pregnancy were divided into experience group,including 60 cases as experience group A( conservative treatment) and 60 cases as experience group B( fallopian tube resection),and 60 healthy women were divided into control group. Compared the anti-Mullerian hormone( AMH),follicle stimulating hormone( FSH),luteinizing hormone( LH),progesterone( P),estradiol( E2) level of each group before and 1 month,3 months after surgery. Results There was no significantly difference between experience group A and control group in the AMH,FSH,LH,P,E2 level before and 1,3 months after the treatment( P > 0. 05); Compared with control group,experience group A in the same period and experience group B patients before the test,AMH and E2 were significantly reduced,FSH significantly increased in experience group B 1 and 3 months postoperative,the differences were statistically significant( P < 0. 01). Conclusion The ovarian reserve function will decrease in patients with ectopic pregnancy after fallopian tubal resection,so we suggest fertility requirements of women of childbearing age to avoid tubal resection,possible conservative treatment,to protect ovarian function.