炎性因子及基质金属蛋白酶水平与房颤的关系分析

The relationship analysis of inflammatory cytokines and matrix metalloproteinase with atrial fibrillation

目的分析炎性因子及基质金属蛋白酶指标与房颤的关系。方法选取2015年1月-2016年3月于该院进行诊治的房颤患者59例作为观察组,另选同时间段的体检健康人员59例作为对照组,检测2组的血清炎性因子及基质金属蛋白酶指标并比较,同时比较观察组中不同临床分类与欧州心律学会(EHRA)分级患者的上述指标,并采用Logistic分析炎性因子及基质金属蛋白酶指标与房颤的关系。结果观察组的血清炎性因子及基质金属蛋白酶指标均高于对照组,且不同临床分类与EHRA分级患者的上述血清指标也存在明显差异(P均<0.05),Logistic分析显示,炎性因子及基质金属蛋白酶指标均与房颤有密切的关系(P均<0.05)。结论房颤患者的血清炎性因子及基质金属蛋白酶指标均呈现高表达状态,且患者的临床分类与EHRA分级对其表达影响较大,与疾病有密切的关系,应给予积极的监测与干预。

Objective To analyse the relationship among inflammatory cytokines,matrix metalloproteinase and atrial fibrillation. Methods Selected 59 cases patients with atrial fibrillation from January 2015 to March 2016 in our hospital as observer group. Selected 59 casese health personnel as control group. Compared the serum inflammatory factors and matrix metalloproteinase of two groups. Compared the level of serum inflammatory factors and matrix metalloproteinase in different clinical classification and European Heart Rhythm Society( EHRA) Classification. The relationship among inflammatory cytokines,matrix metalloproteinase and atrial fibrillation was analysised by logistic analysis. Results The level of serum inflammatory factors and matrix metalloproteinase in observe group were higher than that of control group,the level of serum inflammatory factors and matrix metalloproteinase in different clinical classification and EHRA classification has statistically significant( P <0. 05). After logistic analysis,inflammatory cytokines and matrix metalloproteinases indicators were closely related with atrial fibrillation( P < 0. 05). Conclusion Serum inflammatory cytokines and matrix metalloproteinases in patients with atrial fibrillation index showed a high expression of state. The clinical classification and EHRA classification has a large influence on the expression of serum inflammatory cytokines and matrix metalloproteinases,witch should be given active monitoring and intervention.