重组人脑利钠肽治疗慢性阻塞性肺疾病合并急性左心衰竭的临床效果观察

The clinical effect observation of recombinant human brain natriuretic peptide in chronic obstructive pulmonary disease with acute left heart failure clinical observation

目的观察重组人脑利钠肽(rh BNP)治疗慢性阻塞性肺疾病(COPD)合并急性左心衰竭患者的治疗效果。方法将COPD合并急性左心衰竭患者50例随机分为研究组和对照组各25例。比较2组临床疗效、心率、血压、尿量、心功能、血气分析指标的变化情况,以及常规抗心力衰竭药物的使用剂量和不良反应发生率。结果研究组总有效率为92.0%高于对照组的68.0%,差异有统计学意义(P<0.05);治疗前2组患者心率、血压、尿量、心功能、血气分析指标比较差异均无统计学意义(P>0.05),治疗后2组患者心率、血压均无显著差异(P>0.05),但研究组尿量显著高于对照组(P<0.05);治疗后2组脑利钠肽(BNP)、左室射血分数(LVEF)、左室舒张末容积(LVDD)、动脉血气分析等指标比较差异均有统计学意义(P<0.05)。研究组常规心力衰竭药物的使用剂量及不良反应的发生率均低于对照组,差异均有统计学意义(P<0.05)。结论 rh BNP治疗COPD合并急性左心衰竭患者疗效显著,不仅能有效缓解患者的临床症状,改善心功能,且能减少常规心力衰竭药物的使用剂量,降低不良反应的发生,值得临床推广应用。

Objective To observe the effect of recombinant human brain natriuretic peptide in chronic obstructive pulmonary disease( COPD) with acute left heart failure clinical observation. Methods 50 cases patients with COPD combined with acute left heart failure were randomly divided into research group and control group,each of 25 cases. After treatment,compared the Clinical efficacy,heart rate,blood pressure,urine,heart function,blood gas analysis of changes,and the dosage and side effects of conventional anti-heart failure drugs in 2 groups. Results The total effect of research group( 92. 0%) was higher than that of control group( 68. 0%),the difference was statistically significant( P < 0. 05). The level of heart rate,blood pressure,urine,heart function,blood gas analysis of 2 groups before treatment was no statistically significant( P > 0. 05). After treatment,the change of heart rate,blood pressure was no statistically significant( P > 0. 05). The urine of research group after treatment was higher than that of control group( P < 0. 05). The difference of BNP,LVEF,LVDD and arterial blood gas analysis in 2 group after treatment was statistically significant( P < 0. 05). The drug dosage and adverse reactions rates of research group were lower than that of control group,the difference was statistically significant( P < 0. 05). Conclusion rh BNP in COPD combined with acute left ventricular failure has an good effect,not only can effectively alleviate the clinical symptoms,improve heart function,and can reduce the dosage of conventional drugs,reduce the incidence of adverse reactions,worthy of clinical application.